Emerging roles of β-arrestins
Emerging roles of β-arrestins
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DOI：
10.4161/cc.5.18.3212
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发表时间：
2006-09-15
期刊：
影响因子：
4.3
通讯作者：
DuBois, Raymond N.
中科院分区：
文献类型：
--
作者：
Buchanan, F. Gregory;DuBois, Raymond N.
抑制蛋白最初被定性为结构接头蛋白，可调节七跨膜受体的脱敏和运输。从这些开创性的观察中，这个基因家族出现了许多新功能。在这里，我们回顾了最近发现的 β-arrestin 的作用，包括其核功能以及在发育、细胞迁移和转移中的作用。
Arrestins were originally characterized as structural adaptor proteins which modulate the desensitization and trafficking of seven-membrane-spanning receptors. From these seminal observations a multitude of novel functions for this gene family have arisen. Here we review the recently identified roles for beta-arrestin including its nuclear function and roles in development, cellular migration, and metastasis.