Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine.
Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine.
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终末期肾衰竭尿毒症患者循环中白蛋白连接和游离形式的戊糖素的积累：戊糖素病理生理学中的肾脏影响。
DOI：
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发表时间：
1996
影响因子：
13.6
通讯作者：
K. Maeda
中科院分区：
文献类型：
--
作者：
T. Miyata;Y. Ueda;T. Shinzato;Y. Iida;Shoichiro Tanaka;K. Kurokawa;C. van Ypersele de Strihou;K. Maeda
戊糖苷是一种晚期糖基化终产物，其形成与氧化过程密切相关。最近的研究表明，戊糖苷不仅在糖尿病患者的血浆和基质蛋白中增加，而且在非糖尿病血液透析患者中也明显增加。目前，血液透析患者体内戊糖苷形成的蓄积机制和动力学尚不清楚。尿毒症血浆的凝胶过滤显示，血浆戊糖苷存在于白蛋白组分中（约90%），有趣的是，也以游离形式存在（约5%）。在肾功能正常的受试者中，血浆游离戊糖苷检测不到。血液透析患者血浆中的白蛋白结合戊糖苷酶和游离戊糖苷酶水平之间存在显著相关性。动力学研究表明，膳食戊糖苷被吸收到循环中，无论是口服或静脉注射给药后，戊糖苷的完整或肾切除大鼠，血浆游离戊糖苷水平与肾功能的水平密切相关。这些研究结果表明：（1）戊糖苷在尿毒症患者的循环中以白蛋白连接和游离形式蓄积;（2）膳食戊糖苷可被吸收到循环中，因此是循环游离戊糖苷的一个可能来源;（3）游离戊糖苷可能因肾小球滤过降低而蓄积;（4）白蛋白连接戊糖苷蓄积的机制与高葡萄糖水平无关。这表明在肾衰竭期间，未知的戊糖苷前体或糖氧化催化剂同时蓄积，与葡萄糖无关。
Pentosidine is an advanced glycation end product and its formation is shown to be closely related to oxidative processes. Recent studies have shown that pentosidine levels are increased not only in plasma and matrix proteins from diabetic patients, but also markedly in nondiabetic hemodialysis patients. Currently, the mechanism of accumulation and kinetics of pentosidine formation in hemodialysis patients remain unknown. Gel filtration of uremic plasma revealed that plasma pentosidine exists in the albumin fraction (approximately 90%) and, interestingly, in free form (approximately 5%) as well. Plasma free pentosidine was undetectable in subjects with normal renal function. There was a significant correlation between the plasma levels of albumin-linked and free pentosidine in hemodialysis patients. Kinetic studies indicated that dietary pentosidine was absorbed into the circulation and that, after either oral or intravenous administration of pentosidine to intact or nephrectomized rats, the plasma free pentosidine level was closely linked to the level of renal function. These findings demonstrate that: (1) Pentosidine accumulates as albumin-linked and in free form in the circulation of uremic patients; (2) dietary pentosidine can be absorbed into the circulation, thus being one possible origin of circulating free pentosidine; (3) free pentosidine may accumulate as a result of decreased glomerular filtration; and (4) the mechanism of accumulation of albumin-linked pentosidine is not related to high glucose levels. It suggests the simultaneous accumulation, during renal failure, of either unknown pentosidine precursor(s) or catalyst(s) of glycoxidation, independent of glucose.
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影响因子：
2.9
作者：
REDDY, S;BICHLER, J;BAYNES, JW
通讯作者：
BAYNES, JW
影响因子：
15.9
作者：
SCHMIDT, AM;YAN, SD;STERN, D
通讯作者：
STERN, D
DOI：
10.1056/nejm198805193182007
发表时间：
1988-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
M. Brownlee;A. Cerami;H. Vlassara
通讯作者：
M. Brownlee;A. Cerami;H. Vlassara
DOI：
10.1073/pnas.93.6.2353
发表时间：
1996-03-19
影响因子：
11.1
作者：
Miyata, T;Taneda, S;Monnier, VM
通讯作者：
Monnier, VM
DOI：
10.1016/s0021-9258(17)36966-1
发表时间：
1994-04
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Shi Du YanS;A. Schmidt;Mark Anderson;Jinghua Zhang;J. Brett;Y. Zou;D. Pinsky;David SternSn
通讯作者：
Shi Du YanS;A. Schmidt;Mark Anderson;Jinghua Zhang;J. Brett;Y. Zou;D. Pinsky;David SternSn