Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: The Framingham Heart Study
Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: The Framingham Heart Study
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DOI：
10.1111/j.1523-1755.2004.00973.x
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发表时间：
2004-11-01
影响因子：
19.6
通讯作者：
O'Donnell, CJ
中科院分区：
文献类型：
--
作者：
Fox, CS;Larson, MG;O'Donnell, CJ
背景在终末期肾病（ESRD）患者中，心血管疾病的风险比一般人群高10至20倍。通过电子束计算机断层扫描（EBCT）检测，ESRD成人患者的冠状动脉钙化（CAC）增加。由于即使在肾功能中度下降时冠心病的风险也会增加，因此我们试图测试在肾功能轻度下降的患者中是否可以看到高CAC评分。无症状性心血管疾病的男性和女性接受EBCT。使用Agatston描述的方法定量冠状动脉钙。通过肾小球滤过率（GFR）评估肾功能。采用斯皮尔曼相关系数分析GFR与CAC的相关性。319例受试者（162例男性/157例女性），平均年龄60岁。平均GFR为86+/-23 mL/min/ 1.73 m2（范围：31-169; GFR为10%
Background. Among patients with end-stage renal disease (ESRD), the risk of cardiovascular disease is 10 to 20 times higher than the general population. Adults with ESRD have increased coronary-artery calcification (CAC) detected by electron-beam computed tomography (EBCT). Because the risk of coronary heart disease is increased even at moderate declines in kidney function, we sought to test whether high CAC scores are seen among those with mild reductions in kidney function.Methods. Men and women free of symptomatic cardiovascular disease underwent EBCT. Coronary calcium was quantified using the method described by Agatston. Renal function was estimated by glomerular filtration rate (GFR). Spearman correlation coefficients were used to test the association between GFR and CAC.Results. Three hundred nineteen subjects (162 men/157 women), mean age 60, were included. Mean GFR was 86+/-23 mL/min/ 1.73 m(2) (range 31-169; 10% with GFR