Total Synthesis of the Anti-Apoptotic Agents Iso- and Bongkrekic Acids
Total Synthesis of the Anti-Apoptotic Agents Iso- and Bongkrekic Acids
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DOI：
10.1021/ol902676t
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发表时间：
2010-01-15
期刊：
影响因子：
5.2
通讯作者：
Ley, Steven V.
中科院分区：
文献类型：
--
作者：
Francais, Antoine;Leyva, Antonio;Ley, Steven V.
本文报道了异邦克酸的首次收敛全合成，涉及三种不同的立体定向钯交叉偶联形成二烯单元。还证明了通过该途径获得米松酸。这些合成涉及几个潜在的通用构件的形成。
The first convergent total synthesis of isobongkrekic acid is reported Involving three different stereospecific palladium cross-couplings for the formation of the diene units. Access to bongkrekic acid by this route Is also demonstrated. These syntheses involve the formation of several potentially general building blocks.