INVOLVEMENT OF THE AMYGDALA GABAERGIC SYSTEM IN THE MODULATION OF MEMORY STORAGE
INVOLVEMENT OF THE AMYGDALA GABAERGIC SYSTEM IN THE MODULATION OF MEMORY STORAGE
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DOI：
10.1016/0006-8993(89)90945-1
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发表时间：
1989-05-15
期刊：
影响因子：
2.9
通讯作者：
MCGAUGH, JL
中科院分区：
文献类型：
--
作者：
BRIONI, JD;NAGAHARA, AH;MCGAUGH, JL
这些实验检测了杏仁复合体的内在GABA能系统在记忆储存调节中的参与。在大鼠杏仁核中长期植入双侧插管，进行抑制性回避任务训练，并在训练后双侧杏仁核内注射GABA受体拮抗剂甲碘荷包牡丹碱（BMI）（0.1-1.0 nmol）或GABAA受体激动剂蝇蕈醇（0.001-0.1 nmol）。如48小时保留测试的性能所示，BMI增强抑制性回避条件反射的保留，而蝇蕈醇损害保留。BMI（0.1 nmol）产生的记忆增强剂量低于诱导惊厥所需的剂量。训练后注射BMI不影响保留时，注射到尾壳核背侧杏仁核。这些结果表明，杏仁体GABA能系统参与了记忆储存的调节。
These experiments examined the involvement of the intrinsic GABAergic system of he amygdaloid complex in the modulation of memory storage. Rats were chronically implanted with bilateral cannulae in the amygdala, trained in an inhibitory avoidance task, and given post-training bilateral intra-amygdala injections of either the GABA receptor antagonist bicuculline methiodide (BMI) (0.1-1.0 nmol) or the GABAA receptor agonist muscimol (0.001-0.1 nmol). As indicated by performance on a 48 h retention test, BMI enhanced retention of the inhibitory avoidance conditioning, while muscimol impaired retention. The memory-enhancement obtained with BMI (0.1 nmol) was produced by a dose lower than that necessary to induce convulsions. Post-training injections of BMI did not affect retention when injected into the caudate-putamen dorsal to the amygdala. These results suggest that the amygdaloid GABAergic system is involved in the modulation of memory storage.