Simultaneous detection of IFN-gamma and IL-4 in lesional tissues and whole unstimulated saliva from patients with oral lichen planus
Simultaneous detection of IFN-gamma and IL-4 in lesional tissues and whole unstimulated saliva from patients with oral lichen planus
复制标题
口腔扁平苔藓患者病灶组织和未刺激唾液中IFN-γ和IL-4的同时检测
DOI：
10.1111/j.1600-0714.2007.00593.x
复制
发表时间：
2008-02-01
影响因子：
3.3
通讯作者：
Cheng, Bin
中科院分区：
文献类型：
--
作者：
Tao, Xiao-an;Li, Chun-yang;Cheng, Bin
背景技术背景：虽然在过去的几十年中，干扰素（IFN）-γ和白细胞介素（IL）-4在口腔扁平苔藓（OLP）中的作用已被广泛描述，但现有的结果是有争议的。方法：同时检测不同临床表现的OLP患者皮损和非刺激性唾液（WUS）中IFN-γ和IL-4的含量，并与对照组比较。在OLP病变中，炎性/溃疡性OLP中IFN-γ和IL-4均显著高于对照标本。然而，在WUS中，与对照组相比，仅炎性/溃疡性OLP的IFN-γ增加。结论：IFN-γ和IL-4在口腔扁平苔藓的发病机制中可能起着重要作用，其变化可反映口腔扁平苔藓的病变状态。
BACKGROUND: Although the roles of interferon (IFN)-gamma and interlekin (IL)-4 in oral lichen planus (OLP) have been described extensively in past decades, the available results are controversial. Moreover, few studies have utilized simultaneous detection of cytokines in local tissues and saliva to determine whether salivary cytokines could reflect the fact of local lesions.METHODS: IFN-gamma and IL-4 were determined simultaneously in lesions and whole unstimulated saliva (WUS) from OLP patients with various clinical forms.RESULTS: In OLP lesions, both IFN-gamma and IL-4 in erythematous/ulcerated OLP were higher significantly than that in control specimens. In WUS, however, only IFN-gamma of erythematous/ulcerated OLP was increased compared with control. Remarkably, IFN-gamma and IL-4 in WUS showed a more significant correlation to those in local tissues of all subjects.CONCLUSION: These results indicate that both IFN-gamma and IL-4 may play more important role in pathogenesis of erythematous/ulcerated OLP, and changes of these proinflammatory cytokines in WUS may reflect the status of the OLP lesion.