Is older maternal age a risk factor for preterm birth and fetal growth restriction? A systematic review.
Is older maternal age a risk factor for preterm birth and fetal growth restriction? A systematic review.
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DOI：
10.1080/07399330500230912
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发表时间：
2005-10-01
影响因子：
1.4
通讯作者：
Onyskiw, Judee E
中科院分区：
文献类型：
--
作者：
Newburn-Cook, Christine V;Onyskiw, Judee E
为了确定高龄产妇与不良妊娠结局（早产和小胎龄分娩）之间是否存在关联，我们对1985年至2002年的文献进行了全面检索，并进行了系统回顾。10项研究符合以下纳入标准：(1)按亚型（即特发性早产、胎膜早破）和小胎龄出生（胎儿生长受限）评估早产的危险因素；(2)对这些结果使用可接受的定义；(3) 1985年1月至2002年12月发表的；(4)仅限于考虑特发性早产或胎膜早破或两者兼而有之的早产的研究；(5)限制单胎活产的；(6)在发达国家进行的；(7)以英文出版。回顾的大多数研究发现，母亲年龄较大与早产有关。没有足够的证据来确定母亲年龄较大是否是早产和SGA出生的独立和直接风险因素，或者是通过与年龄相关混杂因素的关联对胎龄或出生体重施加影响的风险标志。未来的研究需要量化延迟生育对新生儿结局的独立和明确的影响，并确定所涉及的途径。
To determine if there was an association between advancing maternal age and adverse pregnancy outcomes (preterm delivery and small-for-gestational-age births), a systematic review was conducted based on a comprehensive search of the literature from 1985 to 2002. Ten studies met the following inclusion criteria: (1) assessed risk factors for preterm birth by subtype (i.e., idiopathic preterm labor, preterm premature rupture of membranes) and small-for-gestational-age (SGA) birth (fetal growth restriction); (2) used acceptable definitions of these outcomes; (3) were published between January 1985 and December 2002; (4) were restricted to studies that have considered preterm birth due to idiopathic preterm labor or premature rupture of membranes or both; (5) were restricted to singleton live births; (6) were conducted in a developed country; and (7) were published in English. The majority of the studies reviewed found that older maternal age was associated with preterm birth. There is insufficient evidence to determine if older maternal age is an independent and direct risk factor for preterm birth and SGA birth, or a risk marker that exerts its influence on gestational age or birth weight or both through its association with age-dependent confounders. Future research is needed to quantify the independent and unconfounded impact of delayed childbearing on neonatal outcomes, as well as to identify the pathways involved.