Preliminary investigation of the mechanisms underlying the effects of manipulation: exploration of a multivariate model including spinal stiffness, multifidus recruitment, and clinical findings.
Preliminary investigation of the mechanisms underlying the effects of manipulation: exploration of a multivariate model including spinal stiffness, multifidus recruitment, and clinical findings.
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对操纵效果的基础机制的初步研究：探索包括脊柱刚度，多杀伤性募集和临床发现在内的多元模型。
DOI：
10.1097/brs.0b013e318216337d
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发表时间：
2011-10-01
期刊：
影响因子：
3
通讯作者：
Childs JD
中科院分区：
文献类型：
--
作者：
Fritz JM;Koppenhaver SL;Kawchuk GN;Teyhen DS;Hebert JJ;Childs JD
Prospective case series. Examine spinal stiffness in subjects with low back pain (LBP) receiving spinal manipulative therapy (SMT), evaluate associations between stiffness characteristics and clinical outcome, and explore a multi-variate model of SMT mechanisms as related to effects on stiffness, lumbar multifidus (LM) recruitment and status on a clinical prediction rule (CPR) for SMT outcomes. Mechanisms underlying the clinical effects of SMT are poorly understood. Many explanations have been proposed, but few studies have related potential mechanisms to clinical outcomes or considered multiple mechanisms concurrently. Subjects with LBP were treated with 2 SMT sessions over 1 week. CPR status was assessed at baseline. Clinical outcome was based on the Oswestry disability index (ODI). Mechanized indentation measures of spinal stiffness and ultrasonic measures of LM recruitment were taken before and after each SMT, and after 1 week. Global and terminal stiffness were calculated. Multivariate regression was used to evaluate the relationship between stiffness variables and percentage ODI improvement. Zero-order correlations among stiffness variables, LM recruitment changes, CPR status, and clinical outcome were examined. Path analysis was used to evaluate a multi-variate model of SMT effects. Forty-eight subjects (54% female) had complete stiffness data. Significant immediate decreases in global and terminal stiffness occurred post-SMT regardless of outcome. ODI improvement was related to greater immediate decrease in global stiffness (p=0.025), and less initial terminal stiffness (p=0.01). Zero-order correlations and path analysis supported a multi-variate model suggesting clinical outcome of SMT is mediated by improvements in LM recruitment and immediate decrease in global stiffness. Initial terminal stiffness and CPR status may relate to outcome though their relationship with LM recruitment. The underlying mechanisms explaining the benefits of SMT appear to be multi-factorial. Both spinal stiffness characteristics and LM recruitment changes appear to play a role.
