Necroptosis and Cancer.
Necroptosis and Cancer.
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DOI：
10.1016/j.trecan.2017.03.002
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发表时间：
2017-04
期刊：
影响因子：
18.4
通讯作者：
Yuan J
中科院分区：
文献类型：
--
作者：
Najafov A;Chen H;Yuan J
坏死性下垂是一种程序性溶解细胞死亡途径，其失控与多种炎症性疾病有关。逃避细胞程序性死亡和炎症在癌症中起着重要的作用，因此，研究坏死性下垂在癌症中的作用一直是人们高度关注的问题。已有研究表明，坏死性下垂会促进癌症转移和T细胞死亡。通过RIPK3表达缺失来逃避坏死性下垂是某些癌症的一个特征。虽然坏死性上睑下垂是癌症治疗的一个有前途的新靶点，但有必要对其在癌症发生中的生物学作用进行进一步研究。在这篇文章中，我们回顾了最近发现的坏死性下垂和癌症之间的相互作用点，并概述了需要进一步研究的主要生物学问题，以期在癌症中以这一途径为靶点。
Necroptosis is a programmed lytic cell death pathway, deregulation of which is linked to various inflammatory disorders. Escape from programmed cell death and inflammation play a significant role in cancer, and therefore, investigating the role of necroptosis in cancer has been of high interest. Necroptosis has been shown to promote cancer metastasis and T cells death. Escape from necroptosis via loss of RIPK3 expression is a feature of some cancers. While necroptosis is a promising novel target for cancer therapies, further investigation into its biological role in carcinogenesis is warranted. In this article, we review the recently-identified interplay points between necroptosis and cancer, and outline major biological questions that require further inquiry on the road to targeting this pathway in cancer.