Expansion of the Hox gene family and the evolution of chordates.
Expansion of the Hox gene family and the evolution of chordates.
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Hox 基因家族的扩展和脊索动物的进化。
DOI：
10.1073/pnas.90.13.6300
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发表时间：
1993
影响因子：
11.1
通讯作者：
Ruddle,FH
中科院分区：
文献类型：
--
作者：
Pendleton,JW;Nagai,BK;Murtha,MT;Ruddle,FH
同源异型盒基因编码DNA结合转录调节因子，参与胚胎模式的形成或在后生动物发育过程中促进细胞类型特异性。调节轴向模式和片段身份的同源异型盒基因（Hox/HOM基因）共享保守的成簇基因组组织。哺乳动物有四个集群，可能是由一个祖先集群的复制产生的。用聚合酶链反应取样法估计了其他后口类中Hox型基因的数目。增加的Hox基因互补与脊索动物和脊椎动物特征的出现相关。我们的数据表明存在一个Hox集群的橡子蠕虫，hemichordate;两个Hox集群的文昌鱼，头索动物;和三个七鳃鳗，一种原始的脊椎动物。
Homeobox genes encode DNA-binding transcription regulators that participate in the formation of embryonic pattern or contribute to cell-type specificity during metazoan development. Homeobox genes that regulate axial patterning and segmental identity (Hox/HOM genes) share a conserved clustered genomic organization. Mammals have four clusters that have likely arisen from the duplication of a single ancestral cluster. The number of Hox-type genes in other deuterostomes was estimated by using a polymerase chain reaction sampling method. Increased Hox gene complements are associated with the appearance of chordate and vertebrate characters. Our data suggest the presence of one Hox cluster in the acorn worm, a hemichordate; two Hox clusters in amphioxus, a cephalochordate; and three in the lamprey, a primitive vertebrate.