Biokinetic Analysis of Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Severe Traumatic Brain Injury Patient Biofluids
Biokinetic Analysis of Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Severe Traumatic Brain Injury Patient Biofluids
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DOI：
10.1089/neu.2010.1564
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发表时间：
2011-06-01
影响因子：
4.2
通讯作者：
Wang, Kevin K. W.
中科院分区：
文献类型：
--
作者：
Brophy, Gretchen M.;Mondello, Stefania;Wang, Kevin K. W.
泛素c端水解酶- l1 （UCH-L1）是一种神经元特异性酶，已被确定为创伤性脑损伤（TBI）的潜在生物标志物。研究目的是确定UCH-L1暴露和动力学指标，确定生物体液之间的相关性，并评估严重TBI患者的预后相关性。数据分析来自一项前瞻性、多中心的重度TBI（格拉斯哥昏迷量表[GCS]评分）研究
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a neuron-specific enzyme that has been identified as a potential biomarker of traumatic brain injury (TBI). The study objectives were to determine UCH-L1 exposure and kinetic metrics, determine correlations between biofluids, and assess outcome correlations in severe TBI patients. Data were analyzed from a prospective, multicenter study of severe TBI (Glasgow Coma Scale [GCS] score