Studies on the Mechanisms of Immunity in Human Schistosomiasis
Studies on the Mechanisms of Immunity in Human Schistosomiasis
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人类血吸虫病的免疫机制研究
DOI：
10.1111/j.1600-065x.1982.tb00372.x
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发表时间：
1982
影响因子：
8.7
通讯作者：
E. Wells
中科院分区：
文献类型：
--
作者：
A. Butterworth;D. Taylor;M. Veith;M. Vadas;A. Dessein;R. Sturrock;E. Wells
与其他寄生虫感染一样，血吸虫病的免疫研究遵循两个不同的方向：第一，使用实验动物模型，无论是自然的还是非自然的宿主-寄生虫组合；第二，使用检测系统来研究免疫效应机制。这两种方法并不是相互排斥的，但都有自己的优缺点。实验动物模型可能允许识别明显参与体内免疫调节的效应器机制。然而，宿主对血吸虫感染的反应似乎存在广泛的物种差异(Smithers&Terry 1976，Phillips&Colley 1978)，并且没有证据表明任何实验动物能够准确地反映人类的情况。相比之下，对VILRO的研究不能提供体内各种效应机制作用的直接证据。然而，它们确实允许比在体内更精确地识别和详细分析每种机制：更重要的是，它们可以用人体材料进行，因此为研究人类免疫提供了一种方法。
Studies on immunity in schistosomiasis, as in other parasitic infections, have followed two distinct directions: first, the use of experimental animal models, in either natural or unnatural host-parasite combinations; and, secondly, the use of assay systems for studying immune effector mechanisms m vilro. Each of these two approaches, which are not mutually exclusive, has its own advantages and disadvantages. The experimental animal models may permit the identification of effector mechanisms that are demonstrably involved in mediating immunity In vivo. However, there appears to be a wide species variation in host response to schistosome infection (reviewed by Smithers & Terry 1976, Phillips & Colley 1978) and there is no evidence that any experimental animal provides an accurate reflection of the situation in man. In contrast, studies in vilro can provide no direct evidence for the role of various effector mechanisms in vivo. However, they do allow a more precise identification and detailed analysis of each mechanism than would be po.ssibie in vivo: and, more importantly, they can be carried out with human materials, and therefore offer an approach to the study of human immunity.
抗体依赖性嗜酸性粒细胞介导的曼氏血吸虫对血吸虫的损害：缺乏氧化代谢的需要。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Pincus,SH;Butterworth,AE;David,JR;Robbins,M;Vadas,MA
通讯作者：
Vadas,MA
DOI：
10.1172/jci110037
发表时间：
1981
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
J. Kazura;M. Fanning;J. Blumer;A. Mahmoud
通讯作者：
J. Kazura;M. Fanning;J. Blumer;A. Mahmoud