Novel triterpenoid saponins from residual seed cake of Camellia oleifera Abel. show anti-proliferative activity against tumor cells
Novel triterpenoid saponins from residual seed cake of Camellia oleifera Abel. show anti-proliferative activity against tumor cells
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油茶籽饼残渣中的新型三萜皂苷。
DOI：
10.1016/j.fitote.2015.05.001
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发表时间：
2015-07-01
期刊：
影响因子：
3.4
通讯作者：
Hou, Ruyan
中科院分区：
文献类型：
--
作者：
Zong, Jianfa;Wang, Ruilong;Hou, Ruyan
从油茶（Camellia oleifera Abel.）山茶皂苷B-1和三个新皂苷：油茶皂苷C-1-C-3（1-3）。它们的结构经鉴定为22-O-当归酰-山茶苷元B 3-O-[beta-D-galactopyranosyl-（1 -> 2）]-[beta-D-galactopyranosyl-（1 -> 2）-alpha-L-arabinopyranosyl-（1 -> 3）]-beta-D-glucopyranosiduronic acid methyl ester（1）; 22-O-当归酰-山茶苷元A3-O-[β-D-吡喃半乳糖基-（1 -> 2）]-[β-D-吡喃葡萄糖基-（1 -> 2）-β-D-吡喃半乳糖基-（1 -> 3）]-β-D-吡喃葡萄糖苷酸甲酯（2）;和28-O-肉桂酰基-山茶苷元B 3-O-[β-D-吡喃半乳糖基z-（1 -> 2）] [β-D-吡喃半乳糖基（1 -> 2）-α-L-吡喃阿拉伯糖基-（1 -> 3）]-β-D-吡喃葡萄糖苷酸甲酯（3）。用BEL-7402、BGC-823、MCF-7、HL-60和KB五种人肿瘤细胞系研究了这四种化合物的抗增殖活性。化合物1、2和山茶皂苷B1具有明显的细胞毒活性。(C)2015 Elsevier B. V.版权所有。
Four oleanane-type triterpenoid saponins were isolated from the seed cake of Camellia oleifera Abel.: camelliasaponin B-1 and three new saponins, oleiferasaponin C-1-C-3 (1-3). Their structures were identified as 22-O-angeloyl-camelliagenin B 3-O-[beta-D-galactopyranosyl-(1 -> 2)]-[beta-D-galactopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl-(1 -> 3)]-beta-D-glucopyranosiduronic acid methyl ester (1); 22-O-angeloyl-camelliagenin A 3-O-[beta-D-galactopyranosyl-(1 -> 2)]-[beta-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-(1 -> 3)]-beta-D-glucopyranosiduronic acid methyl ester (2); and 28-O-cinnamoyl-camelliagenin B 3-O-[beta-D-galactopyranosylz-(1 -> 2)] [beta-D-galactopyranosyl(1 -> 2)-alpha-L-arabinopyranosyl-(1 -> 3)]-beta-D-glucopyranosiduronic acid methyl ester (3) through 1D and 2D NMR, HR-ESI-MS, as well as GC-MS spectroscopic methods. The anti-proliferative activities of these four compounds were investigated on five human tumor cell lines (BEL-7402, BGC-823, MCF-7, HL-60 and KB). Compounds 1 and 2 and camelliasaponin B1 showed significant cytotoxic activities. (C) 2015 Elsevier B.V. All rights reserved.