Crosstalk among Epigenetic Pathways Regulates Neurogenesis.
Crosstalk among Epigenetic Pathways Regulates Neurogenesis.
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DOI：
10.3389/fnins.2012.00059
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发表时间：
2012
影响因子：
4.3
通讯作者：
Zhao X
中科院分区：
文献类型：
--
作者：
Jobe EM;McQuate AL;Zhao X
神经发生过程包括神经干细胞增殖、命运规范、年轻神经元迁移、神经元成熟以及与现有回路的功能整合。尽管神经发生主要发生在胚胎发育期间，但在出生后大脑的有限区域中仍然存在低水平但功能重要的神经发生，包括海马齿状回的颗粒下区和侧脑室的室下区。本综述将涵盖胚胎和成人神经发生，重点是后者。在出生后神经发生的许多内源性介质中，表观遗传途径，例如 DNA 甲基化介质、染色质重塑系统和非编码 RNA 调节剂，似乎发挥着不可或缺的作用。越来越多的证据表明，这些表观遗传因素形成了调控网络，控制着产后神经发生的每一步。在这篇综述中，我们探讨了表观遗传机制，特别是 microRNA、element-1 沉默转录因子/神经元限制性沉默因子 (REST/NRSF)、多梳蛋白和甲基 CpG 结合蛋白在调节出生后和成人神经发生的整个过程中的新兴作用。我们进一步总结了有关这些不同表观遗传蛋白之间的串扰如何形成调节神经元发育的关键调节网络的最新数据。最后，我们讨论这些通路之间的串扰如何将环境线索转化为对神经发生过程的控制。
The process of neurogenesis includes neural stem cell proliferation, fate specification, young neuron migration, neuronal maturation, and functional integration into existing circuits. Although neurogenesis occurs largely during embryonic development, low levels but functionally important neurogenesis persists in restricted regions of the postnatal brain, including the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone of the lateral ventricles. This review will cover both embryonic and adult neurogenesis with an emphasis on the latter. Of the many endogenous mediators of postnatal neurogenesis, epigenetic pathways, such as mediators of DNA methylation, chromatin remodeling systems, and non-coding RNA modulators, appear to play an integral role. Mounting evidence shows that such epigenetic factors form regulatory networks, which govern each step of postnatal neurogenesis. In this review, we explore the emerging roles of epigenetic mechanisms particularly microRNAs, element-1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF), polycomb proteins, and methyl-CpG bindings proteins, in regulating the entire process of postnatal and adult neurogenesis. We further summarize recent data regarding how the crosstalk among these different epigenetic proteins forms the critical regulatory network that regulates neuronal development. We finally discuss how crosstalk between these pathways may serve to translate environmental cues into control of the neurogenic process.
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DOI：
10.1634/stemcells.2008-0519
发表时间：
2008-12
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Barkho BZ;Munoz AE;Li X;Li L;Cunningham LA;Zhao X
通讯作者：
Zhao X
影响因子：
3.7
作者：
Abrajano JJ;Qureshi IA;Gokhan S;Zheng D;Bergman A;Mehler MF
通讯作者：
Mehler MF
影响因子：
64.5
作者：
Bhutani N;Burns DM;Blau HM
通讯作者：
Blau HM
影响因子：
25
作者：
Ballas, Nurit;Lioy, Daniel T.;Grunseich, Christopher;Mandel, Gail
通讯作者：
Mandel, Gail
影响因子：
64.5
作者：
Ballas, N;Grunseich, C;Mandel, G
通讯作者：
Mandel, G