Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.
Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.
复制标题
血清素对葡萄糖和链脲佐菌素治疗的小鼠血糖和胰岛素水平的影响。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
K. Horisaka
中科院分区：
文献类型：
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作者：
Y. Sugimoto;I. Kimura;J. Yamada;Y. Watanabe;N. Takeuchi;K. Horisaka
Effects of serotonin (5-HT) on plasma glucose and serum insulin levels were studied in mice. In normal mice, 5-HT induced a dose-dependent hypoglycemia and an increase in serum insulin levels. 5-HT significantly inhibited glucose-induced hyperglycemia and increased glucose-stimulated insulin release. However, in streptozotocin-induced diabetic mice, 5-HT changed neither the glucose nor insulin levels. These results strongly suggest that 5-HT-induced hypoglycemia is brought on by increasing serum insulin levels.
