Does osteocyte formation cause the nonlinear refilling of osteons?
Does osteocyte formation cause the nonlinear refilling of osteons?
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DOI：
10.1016/s8756-3282(99)00242-2
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发表时间：
2000-01-01
期刊：
影响因子：
4.1
通讯作者：
Martin, RB
中科院分区：
文献类型：
--
作者：
Martin, RB
Marotti(Ital J Anat Embryol 101：25-79,1996)描述了成骨细胞在骨形成过程中向成骨细胞分化的理论。这一理论假设，当先前形成的成骨细胞被新骨和类骨质充分覆盖时，它通过树突向邻近的成骨细胞发出抑制信号，从而降低它们的个体结合率，受这种抑制影响最大的成骨细胞被邻近的成骨细胞掩埋，成为下一层骨细胞之一。通过追求这个概念，本研究发展了一个数学理论来预测另一个关于骨重建的观察：在基本多细胞单位(BMU)再充填过程中，贴壁率的减少，这种贴壁率的下降在骨和表面(例如，小梁)BMU中是不同的，该理论表明，这一结果与整个充填期骨细胞抑制的增加是一致的，在这两种类型的BMU中，骨体积与表面积的不同比率，(C)2000由Elsevier Science Inc.保留所有权利。
Marotti (Ital J Anat Embryol 101:25-79, 1996) described a theory of osteocyte differentiation from osteoblasts during bone formation. This theory postulates that, when a previously formed osteocyte is sufficiently covered by new bone and osteoid, it sends an inhibitory signal through its dendritic processes to the neighboring osteoblasts that reduces their individual apposition rates, The osteoblast most affected by this inhibition becomes buried by its neighbors, and becomes one of the next layer of osteocytes. By pursuing this concept, the present study develops a mathematical theory that predicts another observation about bone remodeling: the diminishment of the apposition rate during the refilling of basic multicellular units (BMUs), This decrease in apposition rate is different in osteonal and surface (e,g,, trabecular) BMUs, and the theory shows that this result is consistent with the accrual of osteocyte inhibition throughout the refilling period, with the different ratios of bone volume to surface area in these two types of BMUs, (C) 2000 by Elsevier Science Inc. All rights reserved.