Nanoparticles from Cuttlefish Ink Inhibit Tumor Growth by Synergizing Immunotherapy and Photothermal Therapy
Nanoparticles from Cuttlefish Ink Inhibit Tumor Growth by Synergizing Immunotherapy and Photothermal Therapy
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墨鱼墨汁纳米颗粒通过协同免疫疗法和光热疗法抑制肿瘤生长
DOI：
10.1021/acsnano.9b02993
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发表时间：
2019-08-01
期刊：
影响因子：
17.1
通讯作者：
Zhang, Xian-Zheng
中科院分区：
文献类型：
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作者：
Deng, Rong-Hui;Zou, Mei-Zhen;Zhang, Xian-Zheng
天然纳米颗粒由于其多样的性质和容易获得而被广泛研究。在这里，从乌贼墨中提取的纳米颗粒（CINPs）具有显着的抗肿瘤效果进行了探索。这些CINPs具有球形形态、良好的生物相容性，富含黑色素，含有多种氨基酸和单糖。CINPs通过激活丝裂原活化蛋白激酶（mitogen-activated protein kinase，MAPK）信号通路，能有效地将肿瘤相关巨噬细胞（tumor-associated macrophages，TAM）从免疫抑制型M2样表型重编程为抗肿瘤型M1样表型。此外，在近红外（NIR）照射下，CINPs具有很强的光热效应和杀伤肿瘤细胞的能力，这使其成为光热治疗（PTT）肿瘤的潜在候选者。在体内，CINPs可以增加MI巨噬细胞的比例并促进细胞毒性T淋巴细胞（CTL）向肿瘤的募集，导致原发性肿瘤生长和肺转移减少。结合它们的光热效应，可以诱导肿瘤特异性抗原的释放，CINPs几乎可以完全抑制肿瘤生长，同时伴有更活跃的免疫反应。总的来说，这里描述的这些CINPs可以提供肿瘤免疫治疗和PTT，这意味着CINPs有希望用于肿瘤治疗。
Natural nanoparticles have been extensively studied due to their diverse properties and easy accessibility. Here, the nanoparticles extracted from cuttlefish ink (CINPs) with significant antitumor efficacy are explored. These CINPs, with spherical morphology, good dispersibility, and biocompatibility, are rich in melanin and contain a variety of amino acids and monosaccharides. Through the activation of mitogen-activated protein kinase (MAPK) signaling pathway, CINPs can efficiently reprogram tumor-associated macrophages (TAMs) from immune-suppressive M2-like phenotype to antitumor M1-like phenotype. Besides, under near-infrared (NIR) irradiation, CINPs exhibit high photothermal effect and tumor cell killing ability, which make them a potential candidate in photothermal therapy (PTT) of tumor. In vivo, CINPs can increase the proportion of MI macrophages and foster the recruitment of cytotoxic T lymphocytes (CTLs) to tumors, leading to reduced primary tumor growth and lung metastasis. In combination with their photothermal effect, which can induce tumor-specific antigens release, CINPs could almost completely inhibit tumor growth accompanied by more active immune responses. Collectively, these CINPs described here can provide both tumor immunotherapy and PTT, implying that CINPs are promising for tumor treatment.