Caloric restriction mimetics: towards a molecular definition
Caloric restriction mimetics: towards a molecular definition
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DOI：
10.1038/nrd4391
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发表时间：
2014-10-01
影响因子：
120.1
通讯作者：
Kroemer, Guido
中科院分区：
文献类型：
--
作者：
Madeo, Frank;Pietrocola, Federico;Kroemer, Guido
热量限制，无论是持续的还是间歇性的，都被认为具有促进健康和延长寿命的作用。热量限制模拟物（CRMs）是模拟热量限制的生物化学和功能效应的化合物。在这篇观点文章中，我们提出了一个统一的定义，CRM作为化合物，通过促进细胞蛋白质的脱乙酰化来刺激自噬。这种去乙酰化过程可以通过三类化合物来实现，这些化合物消耗乙酰辅酶A（AcCoA;乙酰基的唯一供体），抑制乙酰基转移酶（一组使蛋白质阵列中的赖氨酸残基乙酰化的酶）或刺激去乙酰化酶的活性并因此逆转乙酰基转移酶的作用。标准物质的统一定义对于这类治疗药物的持续发展至关重要。
Caloric restriction, be it constant or intermittent, is reputed to have health-promoting and lifespan-extending effects. Caloric restriction mimetics (CRMs) are compounds that mimic the biochemical and functional effects of caloric restriction. In this Opinion article, we propose a unifying definition of CRMs as compounds that stimulate autophagy by favouring the deacetylation of cellular proteins. This deacetylation process can be achieved by three classes of compounds that deplete acetyl coenzyme A (AcCoA; the sole donor of acetyl groups), that inhibit acetyl transferases (a group of enzymes that acetylate lysine residues in an array of proteins) or that stimulate the activity of deacetylases and hence reverse the action of acetyl transferases. A unifying definition of CRMs will be important for the continued development of this class of therapeutic agents.