Altered pain modulation to noxious heat thermal stimuli in burning mouth syndrome
Altered pain modulation to noxious heat thermal stimuli in burning mouth syndrome
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DOI：
10.1111/odi.13486
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发表时间：
2020-08-13
期刊：
影响因子：
3.8
通讯作者：
Noma, Noboru
中科院分区：
文献类型：
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作者：
Nishihara, Chisa;Watanabe, Kosuke;Noma, Noboru
目的 本研究的目的是使用表皮内电刺激 (IES) 检查灼口综合征 (BMS) 患者和健康对照患者的时间总和 (TS) 和条件性疼痛调节 (CPM)。材料和方法 26 名患有 BMS 的女性患者和 27 名健康女性对照参加了本研究。对 BMS 组和对照组参与者的右下巴进行单次电刺激，然后进行一系列 10 次连续刺激。 CPM 是通过 TS 的变化来评估的，TS 的变化是根据这两个测试刺激和随后在 BMS 组和对照组的非惯用手上施加的温（40 摄氏度）和热（47 摄氏度）调节刺激之间的数字疼痛量表数据的差异计算得出的。结果：BMS 组和对照组均存在 TS。 BMS组在47℃条件下的CPM效率显着低于对照组，而在40℃条件下BMS与对照组之间的CPM没有显着差异。结论 这些发现表明 BMS 与抑制性 CPM 缺陷相关，并暗示中枢神经系统参与 BMS 的病理生理学。
Objectives The aim of this study was to examine temporal summation (TS) and conditioned pain modulation (CPM) in patients with burning mouth syndrome (BMS) and healthy controls using intra-epidermal electrical stimulation (IES). Materials and Methods Twenty-six female patients with BMS and 27 healthy female controls participated in this study. A single stimulus with electrical stimulation followed by a train of 10 successive stimuli was administered to the right chin of participants in both the BMS and control groups. CPM was evaluated with the changes of TS calculated from the difference in numerical pain scale data between these two test stimuli and the following warm (40 degrees C) and hot (47 degrees C) conditioning stimuli applied at the non-dominant hand in both the BMS and control groups. Results: TS was present in both the BMS and control groups. CPM in the BMS group was significantly less efficient at the 47 degrees C condition than that in the control group, while no significant difference was observed in the CPM between the BMS and the control groups at the 40 degrees C condition. Conclusion These findings indicate that BMS is associated with a deficit inhibitory CPM and implicate the involvement of the central nervous system in the pathophysiology of BMS.