Thyroid cancer after diagnostic administration of iodine-131
Thyroid cancer after diagnostic administration of iodine-131
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DOI：
10.2307/3579200
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发表时间：
1996-01-01
影响因子：
3.4
通讯作者：
Boice, JD
中科院分区：
文献类型：
--
作者：
Hall, P;Mattsson, A;Boice, JD
为了提供暴露于碘-131后甲状腺癌风险的定量数据，34104例患者接受碘-131诊断后随访长达40年，甲状腺平均剂量估计为1.1 Gy，发生67例甲状腺癌，而预期为49.7例（标准化发病率= 1.35；95%置信区间1.05-1.71）。只有在疑似甲状腺肿瘤的患者中才有明显的癌症增加，而在其他原因的患者中没有发现增加的风险。此外，风险与甲状腺的辐射剂量、照射后的时间或照射时的年龄无关。因此，甲状腺癌的轻微增加似乎是由于潜在的甲状腺疾病，而不是辐射照射。在接受I-131治疗的20岁以下人群中，患癌症的风险（3例，预期为1.8例）比原子弹幸存者数据预测的风险低2-10倍。这些数据表明，延长剂量可能比相同总剂量的急性x射线照射造成的风险更低。(C)辐射研究安全
To provide quantitative data on the risk of thyroid cancer after exposure to I-131, 34,104 patients administered I-131 for diagnostic purposes were followed for up to 40 years, The mean thyroid dose was estimated as 1.1 Gy, and 67 thyroid cancers occurred in contrast to 49.7 expected (standardized incidence ratio = 1.35; 95% confidence interval 1.05-1.71). Excess cancers were apparent only among patients referred because of a suspected thyroid tumor, and no increased risk was seen among those referred for other reasons. Further, risk was not related to radiation dose to the thyroid gland, time since exposure or age at exposure. The slight excess of thyroid cancer thus appeared to be due to the underlying thyroid condition and not radiation exposure. Among those under age 20 years when I-131 was administered, a small excess risk (3 cancers compared to 1.8 expected) was about 2-10 times lower than that predicted from data for the A-bomb survivors. These data suggest that protraction of dose may result in a lower risk than an acute X-ray exposure of the same total dose. (C) 1996 by Radiation Research Safety