Decarboxylative benzylation and arylation of nitriles.
Decarboxylative benzylation and arylation of nitriles.
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腈的脱羧苄基化和芳基化。
DOI：
10.1039/c1cc16011g
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Tunge,JonA
中科院分区：
文献类型：
--
作者：
Recio3rd,Antonio;Heinzman,JeffreyD;Tunge,JonA
氰基乙酸苄酯原位生成Pd-π-苄基配合物，通过金属化丁腈与Pd-π-苄基配合物偶联，实现了丁腈脱羧苄基化反应。此外，α，α-二取代2-甲基呋喃基氰乙酸酯的脱羧偶联可以导致脱羧芳基化或苄基化，具体取决于反应条件。
Decarboxylative benzylation of nitriles is achieved via coupling of metallated nitriles with Pd-π-benzyl complexes that are generated in situ from cyanoacetic benzyl esters. In addition, decarboxylative couplings of α,α-disubstituted 2-methylfuranyl cyanoacetates can lead to either decarboxylative arylation or benzylation depending on the reaction conditions.