Design of pH-responsive nanoparticles of terpolymer of poly(methacrylic acid), polysorbate 80 and starch for delivery of doxorubicin.
Design of pH-responsive nanoparticles of terpolymer of poly(methacrylic acid), polysorbate 80 and starch for delivery of doxorubicin.
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DOI：
10.1016/j.colsurfb.2012.07.015
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
A. Shalviri;Ho-Ka Carol Chan;Gaurav Raval;M. Abdekhodaie;Qiang Liu;H. Heerklotz;X. Wu
中科院分区：
文献类型：
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作者：
A. Shalviri;Ho-Ka Carol Chan;Gaurav Raval;M. Abdekhodaie;Qiang Liu;H. Heerklotz;X. Wu
本工作的重点是设计新的pH响应型纳米颗粒用于抗癌药物阿霉素（Dox）的控制递送。采用一锅法合成了聚甲基丙烯酸-聚山梨醇酯80接枝淀粉（PMAA-PS 80-g-St）纳米颗粒，该方法能够在水介质中同时将PMAA和PS 80接枝到淀粉上并形成纳米颗粒。采用FTIR、1H NMR、TEM、DLS和电位滴定等手段对纳米粒子进行了表征。研究了纳米粒的载药量和体外释放。FTIR和1H NMR证实了接枝物的化学组成。纳米粒子是相对球形的，具有窄的尺寸分布和多孔形态。它们在生理pH范围内表现出pH依赖性溶胀。粒径和相变的大小取决于聚合物的组成和配方参数，如表面活性剂和交联剂的浓度和总单体浓度。具有优化组成的纳米粒显示出对Dox的高负载能力和持续的Dox释放。结果表明，新的pH响应性纳米粒子是有用的控制药物输送。
This work focused on the design of new pH-responsive nanoparticles for controlled delivery of anticancer drug doxorubicin (Dox). Nanoparticles of poly(methacrylic acid)-polysorbate 80-grafted starch (PMAA-PS 80-g-St) were synthesized by using a one-pot method that enabled simultaneous grafting of PMAA and PS 80 onto starch and nanoparticle formation in an aqueous medium. The particles were characterized by FTIR,1H NMR, TEM, DLS, and potentiometric titration. Dox loading and in vitro release from the nanoparticles were investigated. The FTIR and1H NMR confirmed the chemical composition of the graft terpolymer. The nanoparticles were relatively spherical with narrow size distribution and porous morphology. They exhibited pH-dependent swelling in a physiological pH range. The particle size and magnitude of phase transition were dependent on polymer composition and formulation parameters such as concentrations of surfactant and cross-linking agent and total monomer concentration. The nanoparticles with optimized compositions showed high loading capacity for Dox and sustained Dox release. The results suggest that the new pH-responsive terpolymer nanoparticles are useful in controlled drug delivery.