Monitoring airway mucus flow and ciliary activity with optical coherence tomography.
Monitoring airway mucus flow and ciliary activity with optical coherence tomography.
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DOI：
10.1364/boe.3.001978
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发表时间：
2012-09-01
影响因子：
3.4
通讯作者：
Button B
中科院分区：
文献类型：
--
作者：
Oldenburg AL;Chhetri RK;Hill DB;Button B
Muco-ciliary transport in the human airway is a crucial defense mechanism for removing inhaled pathogens. Optical coherence tomography (OCT) is well-suited to monitor functional dynamics of cilia and mucus on the airway epithelium. Here we demonstrate several OCT-based methods upon an actively transporting in vitro bronchial epithelial model and ex vivo mouse trachea. We show quantitative flow imaging of optically turbid mucus, semi-quantitative analysis of the ciliary beat frequency, and functional imaging of the periciliary layer. These may translate to clinical methods for endoscopic monitoring of muco-ciliary transport in diseases such as cystic fibrosis and chronic obstructive pulmonary disease (COPD).
