Association between CD16( ) monocytes in peripheral blood and clinical features and short-term therapeutic effects of polycystic ovary syndrome
Association between CD16( ) monocytes in peripheral blood and clinical features and short-term therapeutic effects of polycystic ovary syndrome
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外周血CD16(+)单核细胞与多囊卵巢综合征临床特征及近期疗效的关系
DOI：
10.1002/ijgo.12779
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发表时间：
2019
影响因子：
3.8
通讯作者：
Zhu Xiaoyong
中科院分区：
文献类型：
--
作者：
Tang Lingli;Ye Jiangfeng;Shi Yingli;Zhu Xiaoyong
目的探讨外周血中CD 16 ++单核细胞与多囊卵巢综合征（PCOS）的临床特征和短期治疗效果的关系。方法本前瞻性横断面研究纳入了2016年6月4日至11月28日在上海某大学附属医院诊断为PCOS的女性患者。患者接受Diane-35、二甲双胍或两者联合治疗3个月。我们收集人体测量指标，并使用流式细胞术检测CD 16 ++monocytes.ResultsThe最终分析包括70例患者：18在黛安-35组，30二甲双胍组，22在黛安-35加二甲双胍组。对照组包括60名无PCOS的妇女。PCOS组CD 16 ++单核细胞比例明显高于非PCOS组（16.05%vs10.73%，P=0.001）。高雄激素血症患者与非高雄激素血症患者的比例差异有统计学意义（13.12% vs 17.30%;P=0.002），治疗前诊断高雄激素血症的准确性中等。我们注意到二甲双胍和Diane-35加metformin.ConclusionsThe比例的CD 16 ++单核细胞是最显着的高雄激素血症治疗前的患者治疗后单核细胞减少。我们的研究结果表明，外周血中的CD 16 ++单核细胞的比例可能与PCOS的炎症状态。
ObjectiveTo evaluate the association between CD16++monocytes in peripheral blood and the clinical features and short‐term therapeutic effects of polycystic ovary syndrome (PCOS).MethodsThis prospective cross‐sectional study included women diagnosed with PCOS at a University Hospital in Shanghai, China, between June 4 and November 28, 2016. Patients received Diane‐35, metformin, or both combined for 3 months. We collected anthropometric measures and used flow cytometry to detect CD16++monocytes.ResultsThe final analysis included 70 patients: 18 in the Diane‐35 group, 30 in the metformin group, and 22 in the Diane‐35 plus metformin group. The control group comprised 60 women without PCOS. The proportion of CD16++monocytes was significantly higher in patients with PCOS than in those with no PCOS (16.05% vs 10.73%;P=0.001). The proportion differed significantly between patients with and those without hyperandrogenism (13.12% vs 17.30%;P=0.002) and showed moderate accuracy in diagnosing hyperandrogenism before treatment. We noted a decrease in monocytes post‐treatment in patients given metformin and Diane‐35 plus metformin.ConclusionsThe proportion of CD16++monocytes was most significantly associated with hyperandrogenism before treatment. Our findings suggest that the proportion of CD16++monocytes in peripheral blood might be related to the inflammatory condition of PCOS.