Changes in Regional Brain Levels of Amino Acid Putative Neurotransmitters After Prolonged Treatment with t he Anticonvulsant Drugs Diphenylhydantoin, Phenobarbitone, Sodium Valproate, Ethosuximide, and Sulthiame in the Rat
Changes in Regional Brain Levels of Amino Acid Putative Neurotransmitters After Prolonged Treatment with t he Anticonvulsant Drugs Diphenylhydantoin, Phenobarbitone, Sodium Valproate, Ethosuximide, and Sulthiame in the Rat
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大鼠长期接受抗惊厥药物苯妥英、苯巴比妥、丙戊酸钠、乙舒酰亚胺和磺胺甲酰脲治疗后，区域脑部氨基酸推定神经递质水平的变化
DOI：
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发表时间：
1981
影响因子：
4.7
通讯作者：
P. Lascelles
中科院分区：
文献类型：
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作者：
P. Patsalos;P. Lascelles
摘要：观察了抗惊厥药物二苯海因(DPH)、苯巴比妥、丙戊酸钠、乙硫胺和磺胺单独及联合用药10天对大鼠脑内局部氨基酸类神经递质(GABA、谷氨酸、天冬氨酸和牛磺酸)浓度的影响。DPH对小脑和下丘脑的影响主要是因为它显著降低了小脑的GABA。牛磺酸和天冬氨酸和下丘脑GABA和天冬氨酸。丙戊酸钠显著提高了大部分地区的GABA和牛磺酸水平。天冬氨酸和谷氨酸受到的影响较小。苯巴比妥显著提高了所有脑区的GABA浓度，而牛磺酸的浓度仅在大脑皮层升高。与其他抗惊厥药物相比，乙硫胺引起的变化较小，而舒硫醚引起的变化复杂。联合应用抗惊厥药物会导致复杂的变化，这表明它们的作用模式不同。
Abstract: The effect of prolonged treatment (10 days) with the anticonvulsant drugs diphenylhydantoin (DPH), phenobarbitone, sodium valproate, ethosuximide and sulthiame, both singly and in combination, on regional rat brain amino acid neurotransmitter concentrations (GABA, glutamate, aspartate and taurine) were assessed. DPH had a major effect in the cerebellum and hypothalamus in that it significantly reduced cerebellar GABA. taurine and aspartate and hypothalamic GABA and aspartate. Sodium valproate significantly elevated GABA and taurine in most regions. Aspartate and glutamate were less affected. Phenobarbitone significantly elevated GABA concentrations in all brain regions, while taurine concentration was only elevated in the cerebral cortex. Ethosuximide induced changes were small compared to the other anticonvulsants while sulthiame produced complex changes. Anticonvulsant drugs administered in combination resulted in complex changes, suggesting that their mode of action is different.