Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis?
Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis?
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DOI：
10.1378/chest.07-2116
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发表时间：
2008-05-01
期刊：
影响因子：
9.6
通讯作者：
Kim, Kyu Rae
中科院分区：
文献类型：
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作者：
Huh, Jin Won;Kim, Dong Soon;Kim, Kyu Rae
背景资料：基质金属蛋白酶（MMP）-7是特发性肺纤维化（IPF）发病机制中的一个关键分子。然而，MMP-7在其他类型的特发性间质性肺炎（HP）中的作用尚未确定。本研究旨在通过比较MMP-7在普通型间质性肺炎（UIP）和隐源性机化性肺炎（COP）中的表达，探讨MMP-7在IIP中的作用。比较正常对照组（n = 5）、IPF组（n = 6）和COP组（n = 11）BALF中MMP和TIMP-1的水平及其在肺组织中的表达结果：UIP和COP之间的BAL液MMP-7水平无显著差异，尽管与正常对照组相比，这两种疾病中的MMP-7水平均较高。结论：MMP-7在IPF和COP的发病机制中均起重要作用，可能不是决定IIP预后或可逆性的关键因素。
Background: Matrix metalloproteinase (MMP)-7 was reported to be a key molecule in the pathogenesis of idiopathic pulmonary fibrosis (IPF) based on the result of microarray analysis and knockout mice. However, the role of MMP-7 has not been determined in other types of idiopathic interstitial pneumonia (HP). The aim of this study was to investigate the role of MMP-7 in IIP by comparing its expression in usual interstitial pneumonia (UIP) and cryptogenic organizing pneumonia (COP).Methods: Levels of MMP and tissue inhibitors of metalloproteinase in BAL fluid and their expression on lung tissues were compared between normal control subjects (n = 5) and the patients with IPF (n = 6) and COP (n = 11).Results: There was no significant difference in BAL fluid MMP-7 levels between UIP and COP, although it was higher in both diseases compared to normal control subjects. Furthermore, the pattern and the degree of MMP-7 expression in lung tissues were also similar in both IPF and COP, whereas MMP-2 level was higher in COP and MMP-9 level was higher in IPF.Conclusion: MMP-7 seems to play an important role in the pathogenesis of not only IPF but also COP; therefore, it may not be the key factor determining the prognosis or reversibility of IIPs.