Dose-Dependence of Transient Respiratory Motion Artifacts on Gadoxetic Acid-Enhanced Arterial Phase MR Images
Dose-Dependence of Transient Respiratory Motion Artifacts on Gadoxetic Acid-Enhanced Arterial Phase MR Images
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DOI：
10.1002/jmri.25764
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发表时间：
2018-02-01
影响因子：
4.4
通讯作者：
Onishi, Hiroshi
中科院分区：
文献类型：
--
作者：
Morisaka, Hiroyuki;Motosugi, Utaroh;Onishi, Hiroshi
目的：比较0.05 mmol/kg和0.025 mmol/kg加多西酸动脉期MRI个体内短暂性呼吸运动伪影的发生情况，评价加多西酸的剂量依赖性。材料与方法：回顾性研究91例患者在1.5T不同时间行动态MRI，一次加多西酸0.05 mmol/kg，另一次加多西酸0.025 mmol/kg。0.05 mmol/kg检查共91次，0.025 mmol/kg检查共375次（由于多例患者多次检查）。选择与0.05 mmol/kg扫描时间最接近的0.025 mmol/kg扫描时间，以尽量减少时间影响。两名放射科医生使用四分制对动脉期图像中的TM伪影进行评分：无、轻度、中度和严重伪影。比较两种方案的结果（0.05 mmol/kg vs全部0.025 mmol/kg， 0.05 mmol/kg vs部分0.025 mmol/kg），并计算中重度伪像的优势比。结果：与全部（17/375 [4%];P < 0.01）或部分（3/91 [3%];P = 0.01）标准剂量扫描相比，双剂量扫描（16/91[17%]）中观察到更多的TM伪影。中重度伪影与较高剂量的比值比为4.99 ~ 5.33。结论：加多赛特酸与TM伪影的发生存在剂量依赖性。
Purpose: To compare the occurrence of transient respiratory motion (TM) artifacts between 0.05 mmol/kg and 0.025 mmol/kg gadoxetic-acid on arterial phase MRI intra-individually for evaluating dose-dependence of gadoxetic acid.Materials and Methods: This retrospective study involved 91 patients who underwent dynamic MRI at 1.5T at different times, one time with 0.05 mmol/kg and the other 0.025 mmol/kg gadoxetic-acid. Examinations with 0.05 mmol/kg totaled 91 scans, and examinations with 0.025 mmol/kg totaled 375 scans (due to multiple exams for several patients). The scan with 0.025 mmol/kg closest in time to the 0.05 mmol/kg scan was selected to minimize temporal effects. Two radiologists graded TM artifacts in the arterial phase images using a four-point scale: no, mild, moderate, and severe artifacts. Results were compared between the two protocols (0.05 mmol/kg versus all 0.025 mmol/kg and 0.05 mmol/kg versus selected 0.025 mmol/kg), and the odds ratio for moderate-to-severe artifacts was calculated.Results: Significantly more TM artifacts were observed in the double dose (16/91 [17%]) scans compared with either all (17/375 [4%]; P < 0.01) or selected (3/91 [3%]; P = 0.01) standard dose scans. The odds ratio of the moderate-to-severe artifacts with the higher dose was 4.99-5.33.Conclusion: There appears to be dose-dependence of gadoxetic-acid and the occurrence of TM artifacts.