Estimation of post-mortem interval using biochemical markers
Estimation of post-mortem interval using biochemical markers
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DOI：
10.1080/00450618.2013.784356
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发表时间：
2014-01-02
影响因子：
1
通讯作者：
Lamont, Iain L.
中科院分区：
文献类型：
--
作者：
Donaldson, Andrea Evelyn;Lamont, Iain L.
确定死后间隔（PMI）或死亡时间是大多数凶杀或未目击死亡调查的关键步骤。然而，目前用于估算PMI的各种方法产生了大量的事后分析窗口，有时彼此矛盾。传统的生物化学方法已经确定了一些在死后发生变化的代谢物，但这些方法尚未广泛适用于确定PMI，因为它们无法产生法医界所要求的精确、可靠和快速的结果。生物化学技术的最新发展开始确定生物标志物，可以提供更准确的PMI估计。这些技术比传统方法更敏感和更具体，并且可以标准化和统计评估，使它们成为有吸引力的方法。在这篇综述中，我们讨论了在死后早期使用生化方法测定PMI，特别关注血液中发生的生化和细胞变化。我们还概述了当前的生化方法和技术，这些方法和技术可用于发现可能有助于确定PMI的新型生物标志物。
Determining the post-mortem interval (PMI) or time of death is a critical step in most homicide or un-witnessed death investigations. However, the various methods currently used in estimating PMI yield large post-mortem windows and sometimes contradict one another. Traditional biochemical methods have identified a number of metabolites that change post mortem, but these have not been widely adapted for determining PMI because they failed to produce precise, reliable, and rapid results required by the forensic community. Recent developments in biochemical technologies are starting to identify biomarkers that may provide a much more accurate PMI estimation. These techniques are more sensitive and specific than traditional methods and can be standardised and statistically assessed, making them appealing methodologies. In this review, we discuss the use of biochemical methods for PMI determination in the early post-mortem period, with a particular focus on biochemical and cellular changes occurring in the blood. We also provide an overview of current biochemical methods and technologies that can be used to discover novel biomarkers that may help to determine PMI.