A RHEUMATOID-ARTHRITIS B-CELL SUBSET EXPRESSES A PHENOTYPE SIMILAR TO THAT IN CHRONIC LYMPHOCYTIC-LEUKEMIA
A RHEUMATOID-ARTHRITIS B-CELL SUBSET EXPRESSES A PHENOTYPE SIMILAR TO THAT IN CHRONIC LYMPHOCYTIC-LEUKEMIA
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DOI：
10.1002/art.1780280903
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发表时间：
1985-01-01
影响因子：
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通讯作者：
JANOSSY, G
中科院分区：
文献类型：
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作者：
PLATERZYBERK, C;MAINI, RN;JANOSSY, G
An abnormal subpopulation of B cells expressing the T1 antigen, which is normally restricted to T cells, was demonstrated in the peripheral blood of 16 patients with rheumatoid arthritis. This T1+ B cell population accounted for a mean of 19.6% (upper limit 48%) of the circulating B cells and did not correlate with clinical disease activity, rheumatoid factor, or drug treatment. The highest percentage of T1+ B cells found in the blood of 8 patients with connective tissue disease, including systemic lupus erythematosus, was 5% of the B cells, and for normal controls, it was 3% of the B cells. As previously reported, we confirmed that the T1+, Ig+ phenotype was a feature of leukemic cells in B-type chronic lymphocytic leukemia. The finding of increased numbers of T1+ B cells in patients with rheumatoid arthritis and those with B-type chronic lymphocytic leukemia raises the possibility that these cells play a role in a spectrum of diseases, including those involving autoimmunity and malignancy.
