Multiple neuronal networks mediate sustained attention
Multiple neuronal networks mediate sustained attention
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DOI：
10.1162/089892903770007416
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发表时间：
2003-10-01
影响因子：
3.2
通讯作者：
Stein, EA
中科院分区：
文献类型：
--
作者：
Lawrence, NS;Ross, TJ;Stein, EA
持续的注意力缺陷发生在几种神经精神疾病中。然而，潜在的神经生物学机制仍然不完全清楚。为此，功能磁共振成像被用来调查的神经基板的持续注意（警觉）使用快速视觉信息处理（RVIP）的任务在25名健康志愿者。为了更好地理解注意力背后的神经网络，确定了任务诱导激活与任务表现相关的大脑区域。执行RVIP任务激活了额叶、顶叶、枕叶、丘脑和小脑区域的网络。任务执行期间的失活出现在前扣带回和后扣带回、岛叶以及左侧颞回和海马旁回。良好的任务表现，定义为更好地检测目标刺激，与主要是右额顶叶区域的激活增强和主要是左颞叶边缘和扣带区的激活减少。因子分析表明，这些性能相关的区域被分为两个独立的网络，包括积极激活和消极激活的相互关联的区域。表现不佳者未能显著激活或停用这些网络，而表现良好者要么激活积极网络，要么停用消极网络，或者两者兼而有之。事实上，这两个增加激活的任务特定的领域和增加失活的任务无关的领域介导的认知功能的基础上良好的RVIP任务的性能表明两个独立的电路，大概反映了不同的认知策略，可以招募执行此警戒任务。
Sustained attention deficits occur in several neuropsychiatric disorders. However, the underlying neurobiological mechanisms are still incompletely understood. To that end, functional MRI was used to investigate the neural substrates of sustained attention ( vigilance) using the rapid visual information processing (RVIP) task in 25 healthy volunteers. In order to better understand the neural networks underlying attentional abilities, brain regions where task-induced activation correlated with task performance were identified. Performance of the RVIP task activated a network of frontal, parietal, occipital, thalamic, and cerebellar regions. Deactivation during task performance was seen in the anterior and posterior cingulate, insula, and the left temporal and parahippocampal gyrus. Good task performance, as defined by better detection of target stimuli, was correlated with enhanced activation in predominantly right fronto-parietal regions and with decreased activation in predominantly left temporo-limbic and cingulate areas. Factor analysis revealed that these performance-correlated regions were grouped into two separate networks comprised of positively activated and negatively activated intercorrelated regions. Poor performers failed to significantly activate or deactivate these networks, whereas good performers either activated the positive or deactivated the negative network, or did both. The fact that both increased activation of task-specific areas and increased deactivation of task-irrelevant areas mediate cognitive functions underlying good RVIP task performance suggests two independent circuits, presumably reflecting different cognitive strategies, can be recruited to perform this vigilance task.