Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres
Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres
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DOI：
10.1016/j.bios.2008.10.018
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发表时间：
2009-03-15
影响因子：
12.6
通讯作者：
Oh, Chil Hwan
中科院分区：
文献类型：
--
作者：
Lee, Sangyeop;Chon, Hyangah;Oh, Chil Hwan
抗体偶联空心金纳米球 (HGN) 已用于对单个 MCF7 细胞中过表达的 HER2 癌症标记物进行 SERS 成像。 SERS 映射图像显示，HGN 比银纳米粒子具有更好的均匀散射特性。结果证明了 HGN 作为高灵敏度和均质传感探针用于活细胞中癌症标记物生物成像的潜在可行性。 (C) 2008 Elsevier B.V. 保留所有权利。
Anti body-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells. (C) 2008 Elsevier B.V. All rights reserved.