Molecular characterization of the hemagglutinin and neuraminidase genes of H5N1 influenza A viruses isolated from poultry in Vietnam from 2004 to 2005
Molecular characterization of the hemagglutinin and neuraminidase genes of H5N1 influenza A viruses isolated from poultry in Vietnam from 2004 to 2005
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DOI：
10.1292/jvms.68.527
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发表时间：
2006-05-01
影响因子：
1.2
通讯作者：
Kawaoka, Yoshihiro
中科院分区：
文献类型：
--
作者：
Muramoto, Yukiko;Le, Thi Quynh Mai;Kawaoka, Yoshihiro
自2003年以来，高致病性H5N1禽流感病毒在许多亚洲国家的家禽、野生水鸟和人类中传播。迄今为止，感染H5N1病毒的患者人数最多的是越南，这些病毒继续在该国家禽中引起暴发。在这里，我们的分子特征的血凝素和神经氨酸酶基因的9个H5N1病毒分离于2004年1月和2005年8月之间，从国内家禽在越南。我们发现，几组高致病性H5N1禽流感病毒在这些鸟类中传播，这表明不同谱系的H5N1病毒已多次传入越南。
Highly pathogenic H5N1 avian influenza A viruses have been spreading among domestic poultry, wild aquatic birds, and humans in many Asian countries since 2003. The largest number of patients, to date, infected with the H5N1 viruses are in Vietnam, where these viruses continue to cause outbreaks in domestic poultry. Here, we molecularly characterized the hemagglutinin and neuraminidase genes of nine H5N1 viruses isolated between January 2004 and August 2005 from domestic poultry in Vietnam. We found that several groups of highly pathogenic H5N1 avian influenza viruses are circulating among these birds, which suggests that H5N1 viruses of different lineages have been introduced into Vietnam multiple times.