Evaluation of focal defects of the nerve fiber layer using optical coherence tomography
Evaluation of focal defects of the nerve fiber layer using optical coherence tomography
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DOI：
10.1016/s0161-6420(99)90118-5
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发表时间：
1999-03-01
期刊：
影响因子：
13.7
通讯作者：
Swanson, E
中科院分区：
文献类型：
--
作者：
Pieroth, L;Schuman, JS;Swanson, E
目的：分析已知神经纤维层（NFL）局灶性缺损的青光眼，将光学相干断层扫描（OCT）结果与临床检查、NFL和立体视神经乳头（ONH）摄影以及Humphrey 24-2视野联系起来。设计：横断面患病率研究。参与者：作者随访了研究组的19例患者和对照组的14例患者。干预：采用内固定技术，以3.4 mm的圆直径环绕ONH进行OCT成像，分析2.5秒内采集的100个OCT扫描点。主要结果测量：使用OCT测量NFL厚度。结果：在大多数具有局灶性NFL缺损的眼睛中，OCT显示在临床检查中可见的与局灶性缺损密切对应的区域中的NFL显著变薄，到无红色照片，以及汉弗莱视野的缺陷光学相干断层扫描（OCT）检测NFL局灶性缺损的敏感性为65%，特异性为81%。结论NFL局灶性缺损的厚度与临床参数具有良好的结构和功能相关性，光学相干断层扫描有助于鉴别青光眼早期NFL局灶性缺损。
Objective: To analyze glaucomatous eyes with known focal defects of the nerve fiber layer (NFL), relating optical coherence tomography (OCT) findings to clinical examination, NFL and stereoscopic optic nerve head (ONH) photography, and Humphrey 24-2 visual fields.Design: Cross-sectional prevalence study.Participants: The authors followed 19 patients in the study group and 14 patients in the control group.Intervention: Imaging with OCT was performed circumferentially around the ONH with a circle diameter of 3.4 mm using an internal fixation technique, One hundred OCT scan points taken within 2.5 seconds were analyzed.Main Outcome Measures: Measurements of NFL thickness using OCT were performed.Results: In most eyes with focal NFL defects, OCTs showed significant thinning of the NFL in areas closely corresponding to focal defects visible on clinical examination, to red-free photographs, and to defects on the Humphrey visual fields. Optical coherence tomography enabled the detection of focal defects in the NFL with a sensitivity of 65% and a specificity of 81%,Conclusions Analysis of NFL thickness in eyes with focal defects showed good structural and functional correlation with clinical parameters, Optical coherence tomography contributes to the identification of focal defects in the NFL that occur in early stages of glaucoma.