DEXAMETHASONE INHIBITION OF THE DEVELOPMENT OF DYSPLASTIC BONY LESIONS IN LP/J MICE
DEXAMETHASONE INHIBITION OF THE DEVELOPMENT OF DYSPLASTIC BONY LESIONS IN LP/J MICE
复制标题
DOI：
10.1177/000348949310201015
复制
发表时间：
1993-10-01
影响因子：
1.4
通讯作者：
CHOLE, RA
中科院分区：
文献类型：
--
作者：
BRODIE, HA;CHANG, PS;CHOLE, RA
据观察，近交系 LP/J 小鼠会自发地出现小骨和耳囊的异常骨病变，并在动物的一生中不断发展。这种遗传性小鼠疾病产生的骨病变与人类鼓室硬化症中所见的骨病变具有一些共同的肉眼和组织学特征。先前对 LP/J 小鼠的研究已经证明了在新形成的骨病变进展过程中免疫介导的损伤的证据。本研究旨在探讨地塞米松对 LP/J 小鼠骨病变发展的影响。目的是试图阐明早期研究中观察到的免疫损伤与发育不良性骨病变进展之间的关系。结果表明，与年龄匹配的生理盐水治疗对照组相比，用地塞米松治疗的 LP/J 小鼠出现的发育不良性骨病变明显减少。实验动物和对照动物之间的中耳积液的数量和细胞结构也存在统计学上的显着差异。
Inbred LP/J mice have been observed to spontaneously develop abnormal bony lesions of the ossicles and otic capsule that progress throughout the life of the animals. This genetically inherited murine disorder produces bony lesions that share some gross and histologic features with bony lesions seen in human tympanosclerosis. Previous studies on LP/J mice have demonstrated evidence of immunologically mediated injury in the progression of the newly forming bony lesions. This study was designed to examine the effects of dexamethasone on the development of the bony lesions in LP/J mice. The purpose was to attempt to elucidate the relationship of the immunologic injury observed in earlier studies and the progression of the dysplastic bony lesions. The results show that LP/J mice treated with dexamethasone developed significantly fewer dysplastic bony lesions compared to the age-matched, saline-treated controls. There was also a statistically significant difference in the quantity and cellularity of the middle ear effusions between the experimental and control animals.