A comparison of the fragmentation thresholds and inertial cavitation doses of different ultrasound contrast agents
A comparison of the fragmentation thresholds and inertial cavitation doses of different ultrasound contrast agents
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DOI：
10.1121/1.1529667
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发表时间：
2003-01-01
影响因子：
2.4
通讯作者：
Crum, LA
中科院分区：
文献类型：
--
作者：
Chen, WS;Matula, TJ;Crum, LA
造影剂气泡破坏在几种新的诊断和治疗应用中是重要的。破坏的压力阈值由外壳材料决定，而气泡经历惯性空化（IC）的倾向取决于超声造影剂（UCA）的气体和外壳性质。三个特定的UCA（Optison，Sonazoid和biSpheres），每个具有不同的外壳和气体属性的超声破碎阈值，在各种声学条件下进行了测定。使用累积宽带噪声发射（IC“剂量”），还比较了由药剂或其衍生物产生的声发射（IC碎裂后的特征）。白蛋白壳的Optison和表面无壳的Sonazoid具有较低的碎裂阈值（在1.1 MHz时平均值分别为0.13和0.15 MPa，在3.5 MHz时平均值分别为0.48和0.58 MPa），而聚合物壳的biSpheres具有显著更高的阈值（在1.1 MHz时平均值分别为0.19和0.23 MPa，薄壳和厚壳双球体在3.5 MHz时分别为0.73和0.96 MPa，p
Contrast bubble destruction is important in several new diagnostic and therapeutic applications. The pressure threshold of destruction is determined by the shell material, while the propensity for of the bubbles to undergo inertial cavitation (IC) depends both on the gas and shell properties of the ultrasound contrast agent (UCA). The ultrasonic fragmentation thresholds of three specific UCAs (Optison, Sonazoid, and biSpheres), each with different shell and gas properties, were determined under various acoustic conditions. The acoustic emissions generated by the agents, or their derivatives, characteristic of IC after fragmentation, was also compared, using cumulated broadband-noise emissions (IC "dose"). Albumin-shelled Optison and surfactant-shelled Sonazoid had low fragmentation thresholds (mean=0.13 and 0.15 MPa at 1.1 MHz, 0.48 and 0.58 MPa at 3.5 MHz, respectively), while polymer-shelled biSpheres had a significant higher threshold (mean=0.19 and 0.23 MPa at 1.1 MHz, 0.73 and 0.96 MPa for thin- and thick-shell biSpheres at 3.5 MHz, respectively, p