(-)Pentobarbital opens ion channels of long duration in cultured mouse spinal neurons.
(-)Pentobarbital opens ion channels of long duration in cultured mouse spinal neurons.
复制标题
(-)戊巴比妥在培养的小鼠脊髓神经元中打开长时间的离子通道。
DOI：
10.1126/science.6248961
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发表时间：
1980
期刊：
影响因子：
56.9
通讯作者：
J. Barker
中科院分区：
文献类型：
--
作者：
D. Mathers;J. Barker
采用电压钳位法在组织培养的小鼠脊髓神经元中进行细胞内记录，研究γ-氨基丁酸和戊巴比妥（-）异构体抑制反应的膜机制。波动分析表明，这两种物质激活离子通道的膜。然而，戊巴比妥激活的通道保持开放的时间是γ-氨基丁酸激活的通道的五倍。
Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to gamma-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by gamma-aminobutyric acid.