Transmembrane control of cadherin-mediated cell-cell adhesion.
Transmembrane control of cadherin-mediated cell-cell adhesion.
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DOI：
10.1006/scel.1993.1021
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发表时间：
1993-06-01
期刊：
影响因子：
--
通讯作者：
Takeichi, M
中科院分区：
文献类型：
--
作者：
Nagafuchi, A;Tsukita, S;Takeichi, M
细胞间粘附分子的钙粘蛋白家族在细胞组织成多细胞结构中起核心作用。钙粘蛋白作用的一个重要特征是它们与细胞骨架蛋白形成复合物，并且这种复合物的形成对于它们的粘附功能至关重要。因此，钙粘蛋白介导的细胞粘附通过与细胞质蛋白的相互作用来控制，并且对于这种控制，可能涉及这些蛋白质的磷酸化以及钙粘蛋白本身。这种细胞粘附的调节机制可能是多种形态发生过程的基础。
The cadherin family of cell-cell adhesion molecules plays a central role in organization of cells into multicellular structures. An important feature of the action of cadherins is that they form a complex with cytoskeletal proteins, and the formation of this complex is crucial for their adhesive function. Cadherin-mediated cell adhesion is thus controlled through the interaction with cytoplasmic proteins, and, for such control, phosphorylation of these proteins and also cadherins themselves might be involved. This regulatory mechanism of cell adhesion is perhaps fundamental to a variety of morphogenetic processes.