Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism.
Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism.
复制标题
血浆磷脂转移蛋白在脂质和脂蛋白代谢中的作用。
DOI：
10.1016/j.bbalip.2011.06.013
复制
发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Cheung MC
中科院分区：
文献类型：
--
作者：
Albers JJ;Vuletic S;Cheung MC
自从世纪前发现PLTP以来，人们对PLTP的生理和病理生理作用的认识大大增加。本文综述了PLTP的基因组织和结构，PLTP的转运特性，PLTP的不同形式，血浆PLTP复合物的特性，血浆PLTP的活性、质量和比活性与脂蛋白和代谢因子的关系，PLTP在脂蛋白代谢中的作用，PLTP与胆固醇逆向转运，PLTP变异体的研究进展，PLTP与胆固醇逆向转运的关系。从动物研究的PLTP的见解; PLTP和动脉粥样硬化; PLTP和信号转导; PLTP在大脑中;和PLTP在人类疾病。PLTP在脂蛋白代谢和血管室脂质转运中的中心作用已被牢固确立。然而，需要更多的研究来进一步阐明PLTP在特定组织中的功能，如肺、脑和脂肪组织。此外，PLTP在人类疾病，如动脉粥样硬化，癌症或神经退行性疾病中发挥的具体作用仍有待澄清。令人兴奋的未来研究方向包括评估PLTP在细胞内脂质代谢和信号转导中的生理相关性，这无疑将促进我们对PLTP在健康和疾病中功能的认识。
The understanding of the physiological and pathophysiological role of PLTP has greatly increased since the discovery of PLTP more than a quarter of century ago. A comprehensive review of PLTP is presented on the following topics: PLTP gene organization and structure; PLTP transfer properties; different forms of PLTP; characteristics of plasma PLTP complexes; relationship of plasma PLTP activity, mass and specific activity with lipoprotein and metabolic factors; role of PLTP in lipoprotein metabolism; PLTP and reverse cholesterol transport; insights from studies of PLTP variants; insights of PLTP from animal studies; PLTP and atherosclerosis; PLTP and signal transduction; PLTP in the brain; and PLTP in human disease. PLTP's central role in lipoprotein metabolism and lipid transport in the vascular compartment has been firmly established. However, more studies are needed to further delineate PLTP's functions in specific tissues, such as the lung, brain and adipose tissue. Furthermore, the specific role that PLTP plays in human diseases, such as atherosclerosis, cancer, or neurodegenerative disease, remains to be clarified. Exciting directions for future research include evaluation of PLTP's physiological relevance in intracellular lipid metabolism and signal transduction, which undoubtedly will advance our knowledge of PLTP functions in health and disease.
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影响因子：
7.7
作者：
Colhoun, HM;Taskinen, MR;Van Tol, A
通讯作者：
Van Tol, A
影响因子：
8.2
作者：
de Vries, R;Kerstens, MN;Dullaart, RPF
通讯作者：
Dullaart, RPF
影响因子：
56.9
作者：
Beamer, LJ;Carroll, SF;Eisenberg, D
通讯作者：
Eisenberg, D
影响因子：
2.9
作者：
CASTRO, GR;FIELDING, CJ
通讯作者：
FIELDING, CJ
DOI：
10.1016/j.bbapap.2011.04.004
发表时间：
2011-07-01
影响因子：
3.2
作者：
Albers, John J.;Day, Joseph R.;Cheung, Marian C.
通讯作者：
Cheung, Marian C.