Early detection of isolated memory deficits in the elderly: the need for more sensitive neuropsychological tests
Early detection of isolated memory deficits in the elderly: the need for more sensitive neuropsychological tests
复制标题
DOI：
10.1017/s003329170200524x
复制
发表时间：
2002-04-01
影响因子：
6.9
通讯作者：
Budge, M
中科院分区：
文献类型：
--
作者：
De Jager, CA;Milwain, E;Budge, M
背景。早期发现老年人的认知能力下降非常重要，因为这可能会先于阿尔茨海默病的进展。本研究的目的是了解敏感的神经心理学测试是否可以识别临床前认知缺陷并描述记忆不佳亚组的认知特征。方法。对 155 名社区居住的老年志愿者进行了神经心理学测试，这些志愿者在入组时接受了 CAMCOG 筛查（平均年龄 74.7 岁）。该电池包括情景记忆测试。语义和工作记忆、语言和处理速度。结果。情景记忆测试 z 分数低于 1 S.D.从队列中平均识别出 25 名具有“非稳健”记忆表现的受试者。使用控制年龄的一般线性模型将该组与剩余的“强大记忆”组进行比较。智商、教育和性别。在情景记忆和语义记忆的所有测试中，测试表现均存在显着差异，但在工作记忆、处理速度和语言测试中则没有显着差异。 CANTAB 配对员工学习和空间识别测试发现，“记忆力不强”组的比例最高。处理速度部分抵消了年龄对整个队列记忆表现的影响。但“非稳健记忆”组的表现与年龄或处理速度无关。结论。敏感的神经心理学测试可以检测出老年人的表现低于正常水平，而他们在 MMSE 和 CAMCOG 测试中的表现完全在正常范围内。老年人群体中与年龄相关的记忆能力下降可能很大程度上是由于该群体中存在未检测到的临床前阿尔茨海默氏病或孤立的记忆障碍。
Background. Early detection of cognitive decline in the elderly is important because this may precede progression to Alzheimer's disease. The aim of this study Was to see Whether sensitive neuropsychological tests could identify pre-clinical cognitive deficits and to characterize the cognitive profile of a subgroup With poor memory.Methods. A neuropsychological test battery was administered to a community-dwelling sample of 155 elderly volunteers Who Were screened With CAMCOG at enrolment (mean age 74.7 years). The battery included tests of episodic memory. semantic and Working memory, language and processing speed.Results. Episodic memory test z scores below 1 S.D. from the cohort mean identified 25 subjects With 'non-robust' memory performance. This group Was compared to the remaining 'robust memory' group with a General Linear Model controlling for age. IQ, education and gender. Test performance Was significantly different in all tests for episodic and semantic memory, but not in tests for working memory, processing speed and language. CANTAB paired associates learning and spatial recognition tests identified the highest percentages of those in the 'non-robust memory' group. Processing speed partialled out the age effect on memory performance for the Whole cohort. but the 'non-robust memory' group's performance Was not associated With age or processing speed.Conclusions. Sensitive neuropsychological tests can detect performance below the norm in elderly people whose performance on MMSE and CAMCOG tests is Well Within the normal range. Age-related decline in memory performance in a cohort of the elderly may be largely due to inclusion within the cohort of individuals with undetected pre-clinical Alzheimer's disease or isolated memory impairment.