BRAIN MALFORMATIONS RELATED TO PRENATAL EXPOSURE TO ETHANOL
BRAIN MALFORMATIONS RELATED TO PRENATAL EXPOSURE TO ETHANOL
复制标题
DOI：
10.1016/s0022-3476(78)80072-9
复制
发表时间：
1978-01-01
影响因子：
5.1
通讯作者：
SMITH, DW
中科院分区：
文献类型：
--
作者：
CLARREN, SK;ALVORD, EC;SMITH, DW
小头畸形和智力迟钝是胎儿酒精综合征的主要特征。本文描述了4例妊娠期间频繁接触大量乙醇的人类新生儿的神经病理结果。宫内暴露于乙醇可能导致大脑结构异常。所有4个大脑都表现出类似的畸形，这是由于神经元和神经胶质元素的迁移错误造成的。脑积水是2例婴儿畸形的一个后果。大脑的改变可能是子宫内乙醇暴露所产生的唯一明显的异常。4例受试者中仅有2例根据外部标准诊断为胎儿酒精综合征。
Microcephaly and mental retardation were principal features of the fetal alcohol syndrome. The neuropathologic findings in 4 human neonates who were exposed to large quantities of ethanol at frequent intervals during gestation were described. Intrauterine exposure to ethanol may result in structural abnormalities of the brain. All 4 brains displayed similar malformations stemming from errors in migration of neuronal and glial elements. Hydrocephalus was 1 consequence of the malformations in 2 infants. The brain alterations may be the only distinct abnormality produced by in utero ethanol exposure. Only 2 of 4 subjects were diagnosed as having the fetal alcohol syndrome from external criteria.