Chiral metal-organic framework used as stationary phases for capillary electrochromatography
Chiral metal-organic framework used as stationary phases for capillary electrochromatography
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DOI：
10.1016/j.aca.2014.04.054
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发表时间：
2014-06-09
影响因子：
6.2
通讯作者：
Yuan, Li-Ming
中科院分区：
文献类型：
--
作者：
Fei, Zhi-Xin;Zhang, Mei;Yuan, Li-Ming
金属有机骨架（MOFs）由于其独特的结构和性质，在分离领域受到了广泛的关注。然而，据我们所知，还没有人试图利用手性MOFs作为毛细管电色谱（CEC）的固定相。本文研究了一种同手性螺旋结构的多金属有机骨架[Zn-2（D-Cam）（2）（4 '，4'-bpy）]（n）（D-Cam = D-（+）-戊酸，4，4 '-bpy = 4，4'-联吡啶）作为开管毛细管电色谱（OT-CEC）手性固定相，用于手性化合物及其同分异构体的分离。使用简单的程序通过将MOFs后涂覆在硅酸钠层上来开发MOFs涂覆柱。黄烷酮和吡喹酮在MOFs涂层柱上实现了基线分离，分离度大于2.10。考察了pH值、有机改性剂含量和缓冲液浓度对分离的影响。此外，还对硝基酚和紫罗兰酮的异构体分离进行了评价。批间、日间和柱间保留时间的相对标准偏差（RSD）分别为1.04%、2.16%和3.07%。结果表明，手性MOFs在手性拆分中具有良好的应用前景。(c)2014年爱思唯尔B。V.保留所有权利。
Metal-organic frameworks (MOFs) have received great attention as novel media in separation sciences because of their fascinating structures and unusual properties. However, to the best of our knowledge, there has been no attempt to utilize chiral MOFs as stationary phases in capillary electrochromatography (CEC). In this study, a homochiral helical MOF [Zn-2(D-Cam)(2)(4',4'-bpy)](n) (D-Cam = D-(+)-camphoric acid, 4,4'-bpy = 4,4'-bipyridine) was explored as the chiral stationary phase in open tubular capillary electrochromatography (OT-CEC) for separation of chiral compounds and isomers. The MOFs coated column has been developed using a simple procedure via MOFs post-coated on the sodium silicate layer. The baseline separations of flavanone and praziquantel were achieved on the MOFs coated column with high resolution of more than 2.10. The influences of pH, organic modifier content and buffer concentration on separation were investigated. Besides, the separations of isomers (nitrophenols and ionones) were evaluated. The relative standard deviations (RSDs) for the retention time of run-to-run, day-to-day and column-to-column were 1.04%, 2.16% and 3.07%, respectively. The results demonstrated that chiral MOFs are promising for enantioseparation in CEC. (c) 2014 Elsevier B. V. All rights reserved.