Open conformation chromatin and pluripotency
Open conformation chromatin and pluripotency
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DOI：
10.1101/gad.1615707
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发表时间：
2007-11-01
影响因子：
10.5
通讯作者：
Niwa, Hitoshi
中科院分区：
文献类型：
--
作者：
Niwa, Hitoshi
多能性，即一个细胞产生一个有机体的所有细胞的能力，是胚胎干细胞的一个迷人而神秘的特征。最近对小鼠胚胎干细胞的广泛分子研究揭示了转录因子网络和表观遗传过程在维持胚胎干细胞多能性中所起的作用(Niwa 2007)。然而，直到上一期的《基因与发育》，陆恭蕙等人(2007年)提出了关于这一缺失环节的新证据，才报道了将这两种机制联系起来的直接证据。
Pluripotency, the ability of a cell to give rise to all of the cells of an organism, is a fascinating and mysterious characteristic of embryonic stem (ES) cells. Recent extensive molecular studies of mouse ES cells have revealed the roles played by transcription factor networks and epigenetic processes in the maintenance of ES cell pluripotency (Niwa 2007). However, no direct evidence to connect these two mechanisms had been reported until in the previous issue of Genes & Development, in which Loh et al.(2007) presented new evidence concerning this missing link.