MRI study of cavum septi pellucidi in schizophrenia, affective disorder, and schizotypal personality disorder
MRI study of cavum septi pellucidi in schizophrenia, affective disorder, and schizotypal personality disorder
复制标题
DOI：
10.1176/ajp.155.4.509
复制
发表时间：
1998-04-01
影响因子：
17.7
通讯作者：
McCarley, RW
中科院分区：
文献类型：
--
作者：
Kwon, JS;Shenton, ME;McCarley, RW
目的：透明隔之间的空腔可能反映了大脑中线结构的神经发育异常。作者检查了精神分裂症、情感障碍、典型人格障碍和正常人的透明隔腔。方法：对30例精神分裂症患者（15例慢性，15例首发），16例情感性精神障碍（首发），21例典型人格障碍患者和46例正常人进行磁共振成像检查。通过计数含有透明隔腔的1.5 mm切片数量评估透明隔腔运行。结果：透明隔腔的存在或不存在没有区分组。然而，异常透明隔腔（即，4个或4个以上切片的透明隔腔）的阳性率在精神分裂症患者中为30.4%（慢性为36.4%，首发为25.0%），在情感性障碍患者中为20.0%，在典型人格障碍患者中为18.8%，在正常人中为10.3%。当作者使用Nopoulos等人。clire？采用透明隔腔分级法，在3个层面上遗漏了与透明隔腔交界的病例，精神分裂症透明隔腔异常检出率为35.0%（慢性40.0%，首发30.0%），情感性精神障碍为25.0%，典型人格障碍为27.3%，正常人为13.0%。精神分裂症患者和正常人之间的评级有统计学显着差异。结论：结果表明，在神经发育过程中中线结构的改变可能在精神分裂症的发病机制中发挥作用。
Objective: A cavum between the septi pellucidi may reflect neurodevelopmental anomalies in midline structures of the brain. The authors examined cavum septi pellucidi in subjects with schizophrenia, affective disorder, and schizotypal personality disorder and in normal subjects. Method: Thirty schizophrenic patients (15 chronic, 15 first-episode), 16 patients with affective disorder (first-episode), 21 patients with schizotypal personality disorder, and 46 normal subjects were evaluated with magnetic resonance imaging. Cavum septi pellucidi runs assessed by counting the number of 1.5-mm slices containing cavum septi pellucidi. Results: The presence or absence of cavum septi pellucidi did not differentiate among groups. However, the prevalence of abnormal cavum septi pellucidi (i.e., cavum septi pellucidi contained on four or more slices) was 30.4% for schizophrenic patients (36.4% for chronic, 25.0% for first-episode), 20.0% for patients with affective disorder, 18.8% for patients with schizotypal personality disorder, and 10.3% for normal subjects. When the authors used the Nopoulos ef al. cl ire?ia for rating cavum septi pellucidi, which omitted borderline cases with cavum septi pellucidi on three slices, the prevalence of abnormal cavum septi pellucidi increased to 35.0% for schizophrenia (40.0% for chronic, 30.0% for first-episode), 25.0% for affective disorder, 27.3% for schizotypal personality disorder; and 13.0% for normal subjects. There was a statistically significant difference in ratings between schizophrenic and normal subjects. Conclusions: The results suggest that alterations in midline structures during the course of neurodevelopment may play a role in the pathogenesis of schizophrenia.