Mortality from dementia in advanced age:: A 5-year follow-up study of incident dementia cases
Mortality from dementia in advanced age:: A 5-year follow-up study of incident dementia cases
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DOI：
10.1016/s0895-4356(99)00067-0
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发表时间：
1999-08-01
影响因子：
7.2
通讯作者：
Winblad, B
中科院分区：
文献类型：
--
作者：
Agüero-Torres, H;Fratiglioni, L;Winblad, B
对包括偶发痴呆症病例在内的77岁以上社区队列的五年随访被用来评估痴呆症对死亡风险的影响，考虑到其他可能与死亡相关的慢性疾病，并对比阿尔茨海默病(AD)和血管性痴呆(VAD)。在这一人群中，70%的痴呆症病例在确诊后五年内死亡，痴呆症死亡率为每100人年2.4人。在控制了社会人口变量和共病后，14%的死亡可以归因于痴呆症，痴呆症受试者的死亡风险是非痴呆者的两倍。AD的死亡危险比为2.0(95%可信区间1.5~2.7)，VaD为3.3(95%可信区间2.0~5.3)。这项研究证实，痴呆症是导致死亡的一个主要风险因素。即使是年龄最大的老年人(85岁以上)，痴呆症也会缩短寿命，特别是在女性中。《CLIN流行病学杂志》58；8：737-743,1999。(C)1999年爱思唯尔科学公司。
Five-year follow-up of a community-based, 77+ old cohort including incident dementia cases was used to evaluate the impact of dementia on the risk of death, taking into account other chronic conditions potentially related to death, and contrasting Alzheimer's disease (AD), and vascular dementia (VaD). In this population, 70% of the dementia cases died during the five years after diagnosis, with a mortality rate specific for dementia of 2.4 per 100 person-years. After controlling for sociodemographic variables and comorbidity, 14% of all deaths could be attributed to dementia with a risk of death among demented subjects twice as high as that for non-demented people. Mortality risk ratios were 2.0 (95% confidence interval 1.5-2.7) for AD and 3.3 (95% confidence interval 2.0-5.3) for VaD. This study confirms that dementing disorders are a major risk factor for death. Even in the oldest old (85+), dementia shortens life, especially among women. J CLIN EPIDEMIOL 58;8:737-743, 1999. (C) 1999 Elsevier Science Inc.