The potential role of tissue-engineered urethral substitution: clinical and preclinical studies
The potential role of tissue-engineered urethral substitution: clinical and preclinical studies
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DOI：
10.1002/term.2112
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发表时间：
2017-01-01
影响因子：
3.3
通讯作者：
Yoo, James J.
中科院分区：
文献类型：
--
作者：
Atala, Anthony;Danilevskiy, Mikhail;Yoo, James J.
尿路狭窄和畸形仍然是泌尿外科的难题之一，尿路成形术是最有效的治疗方案。两种主要类型的尿路成形术是吻合式尿路成形术和用皮瓣或移植物(即替代尿路成形术)加宽尿道腔。然而，到目前为止，还没有找到适合于后者的理想材料。设计和选择这样的材料是一项必要的和具有挑战性的工作，推动了对进一步的生物工程尿路组织研究的需求。本文综述了近年来组织工程学在尿路重建中的应用潜力，特别是在动物和人体模型中应用脱细胞和再细胞组织工程化构建的研究。文中还讨论了该领域未来可能的发展方向。版权所有(C)2015 John Wiley&Sons，Ltd.
Urethral strictures and anomalies remain among the difficult problems in urology, with urethroplasty procedures being the most effective treatment options. The two major types of urethroplasty are anastomotic urethroplasty and widening the urethral lumen using flaps or grafts (i.e. substitution urethroplasty). However, no ideal material for the latter has been found so far. Designing and selecting such a material is a necessary and challenging endeavour, driving the need for further bioengineered urethral tissue research. This article reviews currently available studies on the potentialities of tissue engineering in urethral reconstruction, in particular those describing the use of both acellular and recellularized tissue-engineered constructs in animal and human models. Possible future developments in this field are also discussed. Copyright (c) 2015 John Wiley & Sons, Ltd.