CORTICAL GLUCOSE-METABOLISM IN PARKINSONS-DISEASE WITHOUT DEMENTIA
CORTICAL GLUCOSE-METABOLISM IN PARKINSONS-DISEASE WITHOUT DEMENTIA
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DOI：
10.1016/0197-4580(94)90028-0
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发表时间：
1994-05-01
影响因子：
4.2
通讯作者：
JAGUST, WJ
中科院分区：
文献类型：
--
作者：
EBERLING, JL;RICHARDSON, BC;JAGUST, WJ
有几份报告称帕金森病 (PD) 患者的局部大脑葡萄糖代谢率 (rCMRglc) 降低，但其他报告发现 PD 患者和对照组之间没有差异。 PD 患者认知状态的差异可能是其中一些不一致的原因。我们报告了一项 PET 研究的结果，该研究使用 F-18-氟脱氧葡萄糖 (FDG) 测量 8 名非痴呆 PD 患者的 rCMRglc，其中 6 名患者正在接受多巴胺能药物治疗，另外还有 8 名年龄匹配的对照受试者。我们通过颞叶扫描了一层断层扫描，包括颞叶新皮质和内侧颞叶皮层，并通过基底神经节扫描了一层断层扫描，包括额叶和顶叶皮层。先前确定的速率常数和操作方程用于确定 rCMRglc。平均而言，所有研究区域的 rCMRglc 值比对照值低 23%，其中后脑区域（视觉关联皮层、初级视觉皮层和顶叶皮层）和丘脑的差异最大。这些结果表明，在没有任何明显的认知缺陷的情况下，PD 患者可能表现出新皮质代谢减退，尤其是后脑区域。
There have been several reports of decreased regional cerebral metabolic rates for glucose (rCMRglc) in Parkinson's disease (PD), although others find no differences between PD patients and controls. Differences in the cognitive status of the PD patients may account for some of these inconsistencies. We report the results of a PET study using F-18-fluorodeoxyglucose (FDG) to measure rCMRglc in eight nondemented PD patients, six of whom were receiving dopaminergic medications, and eight age-matched control subjects. We scanned one tomographic level through the temporal lobes that included both temporal neocortex and mesial temporal cortex, and one tomographic level through the basal ganglia that included frontal and parietal cortex. Previously determined rate constants and an operational equation were used to determine rCMRglc. On average, rCMRglc values were 23% below control values for all regions studied, with the greatest differences in posterior brain regions (visual association cortex, primary visual cortex, and parietal cortex) and thalamus. These results indicate that PD patients may show neocortical hypometabolism, especially in posterior brain regions, in the absence of any demonstrable cognitive deficits.