A Streamlined, Green, and Sustainable Synthesis of the Anticancer Agent Erdafitinib
A Streamlined, Green, and Sustainable Synthesis of the Anticancer Agent Erdafitinib
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抗癌剂 Erdafitinib 的简化、绿色和可持续合成
DOI：
10.1021/acs.orglett.3c01380
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发表时间：
2023
期刊：
影响因子：
5.2
通讯作者：
Lipshutz, Bruce H.
中科院分区：
文献类型：
--
作者：
Singhania, Vani;Nelson, Chandler B.;Reamey, Maya;Morin, Emile;Kavthe, Rahul D.;Lipshutz, Bruce H.
Erdafitinib是一种抗癌药物，以三步两锅法合成，涉及在可生物降解的表面活性剂支持的水性胶束条件下运行的ppm水平的Pd催化剂。该工艺具有罐和时间经济性，并消除了与现有路线相关的令人震惊的有机溶剂和有毒试剂。
Erdafitinib, an anticancer drug, was synthesized in a three-step two-pot sequence involving ppm levels of Pd catalyst run under aqueous micellar conditions enabled by a biodegradable surfactant. This process features both pot- and time-economies and eliminates egregious organic solvents and toxic reagents associated with existing routes.