Antidepressant use, depressive symptoms, and incident frailty in women aged 65 and older from the Women's Health Initiative Observational Study.
Antidepressant use, depressive symptoms, and incident frailty in women aged 65 and older from the Women's Health Initiative Observational Study.
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妇女健康计划观察性研究的65岁及65岁妇女的抗抑郁药，抑郁症状和事件脆弱。
DOI：
10.1111/j.1532-5415.2012.03940.x
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发表时间：
2012-05
影响因子：
6.3
通讯作者：
Woods NF
中科院分区：
文献类型：
--
作者：
Lakey SL;LaCroix AZ;Gray SL;Borson S;Williams CD;Calhoun D;Goveas JS;Smoller JW;Ockene JK;Masaki KH;Coday M;Rosal MC;Woods NF
在年龄≥65岁的非虚弱女性中，研究抑郁症状、抗抑郁药的使用和使用时间与三年后发生虚弱的关系。妇女健康倡议观察性研究（WHI-OS）的二次分析，这是一项前瞻性队列研究。WHI-OS在美国40个临床中心进行。年龄在65-79岁之间的女性，在基线时并不虚弱。在基线时通过药物容器检查来评估抗抑郁药的使用情况。根据基线使用和缅甸抑郁筛查（范围0-1，截止值0.06），我们创建了四组：无抑郁症状的抗抑郁药物非使用者（参照组）、有抑郁症状的抗抑郁药物非使用者、无抑郁症状的抗抑郁药物使用者和有抑郁症状的抗抑郁药物使用者。虚弱的组成部分包括缓慢/虚弱、疲惫、低体力活动和意外体重减轻，通过自我报告和基线和第3年的身体测量来确定。在27652名基线妇女中，4.9% （n=1350）为抗抑郁药物使用者，6.5% （n=1794）为抑郁症。在第3年，14.9% （n=4125）虚弱。与参照组相比，所有组发生意外虚弱的风险都增加了。比值比在非抑郁型抗抑郁药服用者中为1.73(95%可信区间(CI) =1.41-2.12)，在抑郁型抗抑郁药服用者中为3.63 （95% CI = 2.37-5.55）。所有使用时间均与发生的虚弱相关（<1年OR = 1.95, 95% CI = 1.41-2.68； 1至3年OR = 1.99, 95% CI = 1.45-2.74； 3年OR = 1.60, 95% CI = 1.20-2.14）。在老年成年妇女中，抑郁症状和抗抑郁药的使用与3年随访后的虚弱相关。
To examine the associations of depressive symptoms, antidepressant use, and duration of use with incident frailty three years later in nonfrail women ≥ age 65. Secondary analysis of the Women’s Health Initiative Observational Study (WHI-OS), a prospective cohort study. WHI-OS was conducted in 40 U.S. clinical centers. Women aged 65-79, not frail at baseline. Antidepressant use was assessed through medication container inspection at baseline. We created four groups according to baseline use and Burnam depression screen (range 0-1, 0.06 cut-off): antidepressant non-users without depressive symptoms (referent group), antidepressant non-users with depressive symptoms, antidepressant users without depressive symptoms, and antidepressant users with depressive symptoms. Frailty components included slowness/weakness, exhaustion, low physical activity, and unintended weight loss, ascertained through self-report and physical measurements at baseline and year 3. Among 27652 women at baseline, 4.9% (n=1350) were antidepressant users and 6.5% (n=1794) were categorized depressed. At year 3, 14.9% (n=4125) were frail. All groups had an increased risk for incident frailty compared to the referent group. Odds ratios ranged from 1.73 (95% Confidence Interval (CI) =1.41-2.12) among non-depressed antidepressant users to 3.63 among depressed antidepressant users (95% CI = 2.37-5.55). All durations of use were associated with incident frailty (<1 year OR = 1.95, 95% CI = 1.41-2.68; 1 to 3 years OR = 1.99, 95% CI = 1.45-2.74; > 3 years OR = 1.60, 95% CI = 1.20-2.14). In older adult women, depressive symptoms and antidepressant use were associated with frailty after 3 years follow-up.
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影响因子：
3.8
作者：
Gallo, JJ;Lebowitz, BD
通讯作者：
Lebowitz, BD
影响因子：
5.6
作者：
Anderson, GL;Manson, J;Prentice, RL
通讯作者：
Prentice, RL
影响因子：
3.7
作者：
Kerse N;Flicker L;Pfaff JJ;Draper B;Lautenschlager NT;Sim M;Snowdon J;Almeida OP
通讯作者：
Almeida OP
影响因子：
17.7
作者：
Iosifescu, DV;Nierenberg, AA;Fava, M
通讯作者：
Fava, M
影响因子：
6.6
作者：
Beekman, ATF;Deeg, DJH;vanTilburg, W
通讯作者：
vanTilburg, W