Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node
Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node
复制标题
DOI：
10.1113/expphysiol.1996.sp003983
复制
发表时间：
1996-09-01
影响因子：
2.7
通讯作者：
Terrar, DA
中科院分区：
文献类型：
--
作者：
Rigg, L;Terrar, DA
Ryanodine和Cyclopiazonic酸被用来改变肌浆网(SR)储存钙的能力。这种干预可显著降低豚鼠窦房结标本的自发搏动频率。此外，这两种药物都降低了从该区域记录到的动作电位的上升速度并改变了其他特征。有人认为，从SR释放的钙在窦房结的起搏中起着重要的作用，这可能是通过调节肌膜离子电流来实现的。
Ryanodine and cyclopiazonic acid were used to alter the ability of the sarcoplasmic reticulum (SR) to store calcium. interventions of this kind significantly reduced the rate of spontaneous beating of guinea-pig sino-atrial node preparations. In addition, both of these drugs decreased the rate of rise and modified other characteristics of the action potentials recorded from this region. It is proposed that calcium released from the SR plays an important, previously unrecognized, role in pacemaking in the sino-atrial node, possibly through regulation of sarcolemmal ionic currents.