Microbubble-enhanced cavitation for noninvasive ultrasound surgery
Microbubble-enhanced cavitation for noninvasive ultrasound surgery
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DOI：
10.1109/tuffc.2003.1244746
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发表时间：
2003-10-01
影响因子：
3.6
通讯作者：
Cain, CA
中科院分区：
文献类型：
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作者：
Tran, BC;Seo, J;Cain, CA
实验探讨了稳定微泡在超声治疗过程中辅助组织消融的潜力。用聚焦超声单次照射原位照射手术切除的犬肾。在每个实验中，多达八个单独的暴露在左肾中。然后同样暴露右肾，但同时持续注入超声造影剂。肾脏切片并检查是否有明显的组织损伤。在有造影剂照射的肾脏中，较低强度和较短时间的暴露更频繁地产生组织损伤。使用250毫秒的暴露，11只动物中有10只（91%）有微泡的肾脏产生的最小损伤强度低于没有微泡的肾脏（对照）。在一项单独的研究中，使用类似3200 W/cm(2)的暴露，在12只动物中有11只（92%）引入微气泡后，产生损伤的最短持续时间缩短了。对于微泡，暴露强度大于或等于800 W/cm(2)，暴露时间大于或等于10 mus时，可观察到的大体组织损伤。组织损伤总强度和持续时间阈值分别降低约2倍和100倍。结果表明，声空化是主要的损伤机制。用稳定的微泡作为空化核来降低体内组织损伤阈值，可能使声空化成为一种更可预测、更实用的无创超声手术机制。
Experiments were conducted to explore the potential of stabilized microbubbles for aiding tissue ablation during ultrasound therapy. Surgically exteriorized canine kidneys were irradiated in situ using single exposures of focused ultrasound. In each experiment, up to eight separate exposures were placed in the left kidney. The right kidney was then similarly exposed, but while an ultrasound contrast agent was continually infused. Kidneys were sectioned and examined for gross observable tissue damage. Tissue damage was produced more frequently, by lower intensity and shorter duration exposures, in kidneys irradiated with the contrast agent present. Using 250-ms exposures, the minimum intensity that produced damage was lower in kidneys with microbubbles than those without (controls) in 10 of 11 (91%) animals. In a separate study using similar to3200 W/cm(2) exposures, the minimum duration that produced damage was shorter after microbubbles were introduced in 11 of 12 (92%) animals. With microbubbles, gross observable tissue damage was produced with exposure intensity greater than or equal tosimilar to800 W/cm(2) and exposure duration greater than or equal to10 mus. The overall intensity and duration tissue damage thresholds were reduced by similar to2x and similar to100x, respectively. Results indicate that acoustic cavitation is a primary damage mechanism. Lowering in vivo tissue damage thresholds with stabilized microbubbles acting as cavitation nuclei may make acoustic cavitation a more predictable, and thus practical, mechanism for noninvasive ultrasound surgery.